磺苄青霉素药物电极的研究

The Study on a PVC Membrane Electrode for Sulbeaicillin

报道了一种磺苄青霉素药物电极,以十六烷基三辛基碘化铵为载体,用邻苯二甲酸二壬酯为增塑剂;运用序贯淘汰水平法对膜组成进行了优化;确定了电极最佳膜组成,讨论了一些因素对电极性能的影响.电极响应快速,选择性、稳定性、重现性均较好.电极检测下限可达1.66×10^(-6)mol/L,线性范围为6.03×10^(-6)～1.0×10^(-1)mol/L,斜率为28.0mV/pC,回收率为96.1％～100.4％.可用于磺苄青霉素药物的分析测定.

In this paper, a PVC membrane electrode is prepared for sulbenicillin, 3,3-dimethyl-7-oxo-6-(2-phenyl-2-sulfoacetamido )-4-thia-1-azabicyclo [3, 2, 0] heptane-2-carboxylic acid, based on its ion pair complexes with hexadecyltrioctylammonium iodide (HTOA). Membrane composition of the electrode was optimized by using the sequential level elimination method for orthogonal experimental design. The electrode has a Nernst response range from 6. 03×10-6-1. 0× 10-1 mol/L with an average slope of 28. 0 mV/pC. The limit of detection is 1. 66×10-6. The electrode responses were not affected by pH in the range 6. 3-7. 0. The electrode was used for determining sulbenicillin in raw material of drug preparation with satisfactory results.