(3-苄基-4-芳酰基-1,2,4-三唑-5-基)(5-本基-1,3,4-噁二唑-2-基)硫醚的合成

Syntheses of (3-Benzyl-4-aroyl-l,2?-triazole-5-yl) (5-phenyI-l, 3?-oxadiazole-2-yl) Sul fides

通过３－苄基－４－芳酰基－１，２，４－三唑－５－巯基负离子在２－甲磺酰基－５－苯基－１，３，４－Ｅ二唑环２－位上的亲核取代反应，制得１３个新的（３－苄基－４－芳酰基－１，２，４－三唑－５－基）（５－苯基－１，３，４－Ｅ二唑－２－基）硫醚衍生物。经元素分析、ＩＲ、＾１Ｈ ＮＭＲ和ＭＳ裂解碎片分析确认结构。初步观察了它们在０．０１％浓度时对大肠杆菌繁殖的抑制作用。

Thirteen new (3-benzyl-4-aroyl-1, 2, 4-triazole-5-yl) (5-phenyl-1, 3, 4-oxadiazole-2-yl) sulfides (2) have been synthesized from the nucleophilic displacement of 3-benzyl-4-aroyl-1, 2,4-triazole-5-hydrosulfuryl anion on the 2-position of 2-methylsulfonyl-5-phenyl-1 ,3, 4-oxadia-zole. The structures of all compounds 2 were confirmed by elemental analysis, IR, 1H NMR and MS.Compounds 2 were screened for their antifungal activity against E. Coli at 0. 01%. The results show that some compounds 2 have stronger inhibiting effects.