摘要
通过3-苄基-4-芳酰基-1,2,4-三唑-5-巯基负离子在2-甲磺酰基-5-苯基-1,3,4-E二唑环2-位上的亲核取代反应,制得13个新的(3-苄基-4-芳酰基-1,2,4-三唑-5-基)(5-苯基-1,3,4-E二唑-2-基)硫醚衍生物。经元素分析、IR、^1H NMR和MS裂解碎片分析确认结构。初步观察了它们在0.01%浓度时对大肠杆菌繁殖的抑制作用。
Thirteen new (3-benzyl-4-aroyl-1, 2, 4-triazole-5-yl) (5-phenyl-1, 3, 4-oxadiazole-2-yl) sulfides (2) have been synthesized from the nucleophilic displacement of 3-benzyl-4-aroyl-1, 2,4-triazole-5-hydrosulfuryl anion on the 2-position of 2-methylsulfonyl-5-phenyl-1 ,3, 4-oxadia-zole. The structures of all compounds 2 were confirmed by elemental analysis, IR, 1H NMR and MS.Compounds 2 were screened for their antifungal activity against E. Coli at 0. 01%. The results show that some compounds 2 have stronger inhibiting effects.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
1993年第10期1383-1386,共4页
Chemical Journal of Chinese Universities
关键词
三唑
E二唑
亲核取代
硫醚
1
2
4-Triazole
1
3
4-Oxadiazole
Nucleophilic displacement
Antifungal activity