2-氨基-5-取代基4-噻唑基膦酸酯的质谱研究

A Study of Mass Spectrometry of 2-Amino-5-substituted-4-thiazolyl Phosphonates

本文对一系列2-氨基-5-取代基-4-噻唑基膦酸酯进行了质谱研究,发现2-氨基-5-取代基-4-噻唑基膦酸酯的膦酰基中的烷基在碎裂过程中产生了一种新的γ-烷基重排反应,并且讨论了这类化合物的质谱碎裂行为,用电子轰击碰撞活化质量分析离子动能谱(EI-CA-MIKES)和高分辨精确质量测量技术(AMMT)作了进一步的研究。

The fragmentation characteristic of a series of recently developed 2-amino-5-substituted-4-thiazolyl-phosphonates is studied by using electron impact (EI), electron impact-collision activity-mass analysed ion kinetic energy spectrometry (EI-CA-MIKES) and accurate mass measurment (AMM ) techniques. It is found that a new type of γ-alkyl rearrangement has occured as evidenced by the'pres-ence of a molecular daughter ion of ethylated thiazole ring(m/z 203). The molecular parent and daughter ions have been fully identified by their unsaturation , accurate ion mass and elementary constitution. The fragmentation pathway is portrayed in a scheme(see Fig. 2)