硫代磷(膦)酰基脲类衍生物的合成及其生物活性

Syntheses and Biological Activities of Thiophosphoryl (Thiophosphonyl) Urea Derivatives

通过O,O-二乙基硫代磷酰基异氰酸酯或O-乙基-苯基硫代膦酰基异氰酸酯与不同胺的加成反应,合成了一系列新型硫代磷(膦)酰基脲类化合物,其结构经元素分析、~1H NMR及MS确证。初步的生物活性测定表明,这类化合物具有一定的除草、抗肿瘤及抑制几丁质形成活性。

The thiophosphoryl(thiophosphonyl) urea uerivatives, R(EtO)P(S)NHC(O)N (R1 )R2, (R =EtO, Ph: R1=alkyl, H; R2 = alkyl, aryl and heterocyclic radical) were synthesized by the addition reaction of R(EtO)P(S)NCO (R = EtO, Ph) to various amines respectively and their structures were confirmed by means of elemental analysis, 1H NMR and MS, Hie preliminary biological tests show that these compounds have herbicidal and anti-tumour activities and could inhibit the formation of chitin.