摘要
ε-聚己内酯(PCL)做为生物医用高分子材料,国外已有不少报道,然而国内研究不多,原因是对材料性能要求苛刻且价格昂贵,对于PCL的合成,目前多采用辛酸亚锡和双金属氧桥烷氧化物为引发剂开环聚合。我们采用价格便宜易得的钛酸丁酯为引发剂制得聚合物与其他方法制得的聚合物在结构与性能上无根本的差别,体外缓释性能实验表明,可望做为某些药物的载体加以使用。
A new synthetic method for biomedical materials poly (e-caprolactone) (PCD initiated by the catalyst Ti(OBu)4 has been investigated. The test has shown that the average degree of polymerization DP is linear with monomer/ initiator M/I. The relationship between the polymer molecular weight Mw and reaction temperature, reaction time also is obtained PCL is characterised by IR, 1H-NMR, 13C-NMR and DSC. The analysis results indicated that PCL synthesized by this method is no difference as compared to that obtained by other methods on polymer structure and performance.In vitro the Nifidipine and Lauryl Alcohol microspheres prepared by the solvent evaporation method using this materials as substrate were found to give excellent sustained release performance.
出处
《高分子学报》
SCIE
CAS
CSCD
北大核心
1993年第3期356-360,共5页
Acta Polymerica Sinica
关键词
钛酸丁酯
聚己内酯
生物材料
Poly(ε-caprolactone), Ti(OBu)4, Nifidipine microsphere, Sustained release