抑制NF-κB激活的策略

Inhibition of NF-κB activation: its approaches

NF κB是一个广泛存在于哺乳动物细胞中的转录因子。它可以参与机体的炎症反应、免疫反应、细胞分化与凋亡及其他应激反应。NF κB启动基因的表达涉及到IKK的激活、IκB磷酸化和泛素化、IκB裂解、NF κB向核内的迁移、NF κB与DNA的结合等过程。NF κB的过度激活会引起一系列的疾病 ,如哮喘、类风湿性关节炎、肠炎等 ,利用药物或通过转基因方法来抑制以NF κB为核心的信号转导途径可能会成为防治某些疾病的途径。

Nuclear factor-κB(NF -κB) is an ubiquitous transcription factor in mammalian cells which is responsible for immune reaction, inflammatory reaction, cell proliferation and apoptosis, as well as other cell stress reactions. Gene expression triggered by NF-κB requires IKK activation, IκB phosphorylation and ubiquitination, IκB degradation, NF-κB nuclear translocation and binding with DNA. Inappropriate and prolonged activation of NF-κB is linked to several diseases including asthma, rheumatoid arthritis and inflammatory bowel disease. Regulation and control of NF-κB can be achieved by pharmacologic inhibition or gene modification strategies of the key components of the cascade that leads to NF-κB activation.