子宫内膜癌HLA-DR表达及其临床意义

Expression of HLA-DR in Endometrial Carcinoma and its Clinical Significance

[目的]探讨HLA鄄DR在子宫内膜癌中的表达及其临床意义。[方法]采用免疫组化SP法检测16例正常子宫内膜、51例子宫内膜癌HLA鄄DR表达,分析其表达与肿瘤进展及生物学恶性程度的关系。[结果]正常子宫内膜HLA鄄DR多数呈阴性表达,而子宫内膜癌中HLA鄄DR表达高于正常子宫内膜。子宫内膜癌中HLA鄄DR表达与临床病理分期、组织分化和淋巴结转移状态有关,但与肌层浸润深度无关。[结论]HLA鄄DR与子宫内膜癌的进展相关,可能作为子宫内膜癌不同发展时期和恶性程度的一个标志物,对于调节内膜癌局部抗肿瘤免疫具有积极的意义。

To investigate the expression of HLA-DR in endometrial carcinoma and its clinical significance. The expression of HLA-DR in 16 cases with normal endometrium and 51 cases with endometrial carcinoma was detected by immunohistochemical SP method. Its relationship to development and biological behavior of endometrial carcinoma was analyzed. The expression of HLA-DR in most cases with normal endometrium was negative. The HLA-DR expression in endometrial carcinoma was significantly higher than that in normal endometrium. HLA-DR expression was correlated with clinicpathological stage, histological gread and lymph node metastasis. No association was found between HLA-DR expression relates to the progress of endometrial carcinoma. It may play an important role in regulating local anti-tumor immunity as a developmental and malignant marker of endometrial carcinoma.