期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

HPV对细胞周期调控影响的研究进展 被引量：4

下载PDF
导出
摘要 人乳头瘤病毒 (HPV)通过其基因产物干扰正常的细胞周期调节 ,延长宿主细胞终末分化时间 ,使病毒易于自身复制。HPVE5 ,E6 ,E7蛋白不仅在细胞转化过程中起重要作用 ,而且是干扰细胞周期调控的重要蛋白。E5主要通过提高丝裂原激活蛋白激酶 (MAP)活性发挥转化作用 ,HPVE6和E7蛋白主要通过与关键细胞周期调节物 (p5 3,pRb)作用 ,使受累细胞绕过细胞周期负性调控因子的调控 ,导致细胞连续增殖及恶性转化。
作者 张洪文 宋丽君
机构地区 中南大学湘雅二医院妇产科
出处 《国外医学（生理病理科学与临床分册）》 2004年第4期325-327,共3页 Foreign Medical Sciences(Pathophysiology and Clinical Medicine)
关键词 人乳头瘤病毒 细胞周期 P53
分类号 R373 [医药卫生—病原生物学]
  • 相关文献

参考文献21

  • 1Helt AM, Galloway DA. Mechanisms by which DNA tumor virus oncoproteins [J]. target the Rb family of pocket proteins Carcinogenesis,2003, 24 (2) : 159-169.
  • 2Hwang SG, Lee D, Kim J, et al. Human papillomavirus type 16 E7 binds to E2FI and activates E2Fl-driven transcription in a retinoblastoma protein-independent manner [ J ]. J Biol Chem,2002,277(4) : 2923-2930.
  • 3Heck DV, Yee CL, Howley PM, et al. Efficiency of binding the retinoblastoma protein correlates with the transforming capacity of the E7 oncoproteins of the human papillomaviruses [ J ]. Proc Natl Acad Sci USA, 1992,89 (10) : 4442-4446.
  • 4Avvakumov N, Torchia J, Mymryk JS. Interaction of the HPV E7 proteins with the pCAF acetyltransferase[ Jl. Oncogene, 2003, 22(25) :3833-3841.
  • 5Young MR, Farrell L, Lambert P, et ul. Protection against human papillomavirus type 16-E7 oncogene- induced tumorigenesis by in vivo expression of dominant-negative c-jun [ J ]. Mol Carcinog,2002,34 (2) :72-77.
  • 6Nishitani J, Nishinaka T, Cheng CH, et al Recruitment of the retinoblastoma protein to c-Jun enhances transcription activity mediated through the AP-I binding site[J]. J Biol Chem, 1999, 274(9) :5454 -5461.
  • 7Giarre M, Caldeira S, Malanchi I, et al. Induction of pRb degradation by the human papillomavirus type 16 E7 protein is essential to efficiently overcome pl6INK4a-imposed G1 cell cycle arrest [ J ]. J Viro1,2001,75 (10) :4705-4712.
  • 8Helt AM, Funk JO, Galloway DA. Inactivation of both the retinoblastoma tumor suppressor and p21 by the human papillomavirus type 16 E7 oncoprotein is necessary to inhibit cell cycle arrest in human epithelial cells[J]. J Virol, 2002, 76 (20) : 10559-10568.
  • 9Pim D, Thomas M, Javier R, et al. HPV E6 targeted degradation of the discs large protein: evidence for the invol vement of a novelubiquitin ligase[J]. Oncogene, 2000,9(6) : 719-725.
  • 10Cooper B, Schneider S, Bohl J, et al. Requirement of E6AP and the features of human papillomavirus E6 necessary to support degradation of p53[J]. Virology, 2003,6(1) :87-99.

同被引文献29

  • 1郭昕.c-myc和p53蛋白在宫颈癌组织中的表达及临床意义[J].局解手术学杂志,2005,14(3):147-148. 被引量：7
  • 2葛静,鲁永鲜.HPV与宫颈癌关系及疫苗研究进展[J].国外医学（病毒学分册）,2005,12(5):129-132. 被引量：14
  • 3修晓新,张淑兰.HPVE6、E7与端粒酶激活研究进展[J].国外医学（计划生育．生殖健康分册）,2006,25(3):164-167. 被引量：1
  • 4成海恩,张溢,张翠莉,潘巍巍,石华,何柳兴,易发平,宋方洲.HPV-16E6基因沉默对宫颈癌CaSki细胞的影响[J].第四军医大学学报,2006,27(20):1888-1891. 被引量：4
  • 5Gihson SL,Dai CY,Lee HW,et al.Inhibition of coloon tumur progression and angiogenesis by the INK4a/arf locus.Cancer Res,2003,63:742-746.
  • 6Beenken SW,Bland KI.Biomarkers for breast cancer.Minerva Chir,2002,57:437-448.
  • 7Carreras R,alameda F,ManceboG,et al.A study of Ki-67,c-erbB2and cyclin D1 expression in CIN Ⅰ,CIN Ⅲ and squamous cell carcinoma of the cervix.Histol Histopathol,2007,22:587-592.
  • 8Keating.JT,Cyikn A,Riethdorf S,et al.Ki-67,cyclin E and P16ink4n are complimentary surrogate biomarkers for human papilloma virus related cervical ncoplasia.Am J Surg Pathol,2001,25:884-891.
  • 9Wensveen CW,Kagie MJ,Veldhuizen RW,et al.Combining HPV and MIB-1 tests reduces the number of colposcopies in women with equivocal cytology.Acta obstet Gynecol scand,2006,85:1491-1495.
  • 10Takashi Yugawa,Tohru Kiyono.Molecular mechanisms of cervical carinogenesis by high-risk human papillamaviru-ses:novel functions of E6 and E7 oncoproteins[J].Rev Med Virol,2009,19:97-113.

引证文献4

二级引证文献10

国外医学（生理病理科学与临床分册）
2004年 第4期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部