再生丝素蛋白/海藻酸盐包药微胶囊的结构与释药性能

Structure and Controlled Release of Medicine Microcapsule Wrapped with Fibroin-alginate

以模型药物消炎痛(吲哚美辛)作囊芯,再生丝素蛋白和海藻酸盐(FB/AG)作囊膜,在液体石蜡,Span-80的W/O型乳化体系中于50～60℃,高速搅拌下,采用复凝聚法制备包药微胶囊。采用扫描电镜(SEM)、激光粒度仪、X ray、FTIR、DSC等测定并表征了包药微胶囊的结构。结果显示,微胶囊呈近似球型,粒径为65μm左右,粒径呈正态分布,再生丝素蛋白与海藻酸盐之间具有相互作用,结晶程度提高。采用药物体外释放法测其释药性能,该包药微胶囊24h的释药率为24%,海藻酸盐微胶囊为42%,药粉为80%,FB/AG具有缓释效果。

In the liguid paraffin and span-80 W/O emulsion system, using Indomethacin as core material and glutaraldhyde as crosslinking agent,emulsifying at 50～60 ℃ with high-speed stirring,the medicine microcapsule wrapped with fibroin-alginate(FB/AG) was prepared using complex coacervation method.Its structure was determined and expressed by SEM,Laser particle sizer,X-ray,FTIR and DSC.The results indicate that the microcapsule is approximatively global with particle size about 65 μm and uniform particle size distribution.There appeares interaction between fibroin and alginate and the crystallinity increases.The results of medicine release show that FB/AG microcapsule has good controlled release effect:the release rate in 24 h is 24%,while that of AG microcapsule is 42% and that of medicine power is 80%.