血清同型半胱氨酸水平与冠状动脉病变的关系

The relationship between the level of serum homocysteine and the diseased coronary arteries

目的 探讨血清同型半胱氨酸 (Hcy)水平与冠状动脉病变的发生及其严重程度的关系。方法 测定 6 7例经冠状动脉造影证实存在冠状动脉病变的患者和 4 3例冠脉造影完全正常者的Hcy水平 ,以Gensini积分系统对冠状动脉病变的严重程度进行评价 ,结合其他心血管危险因素进行统计分析。结果 冠脉病变组的Hcy水平明显比冠脉正常组高(P <0 0 5 )。Logistic回归显示Hcy是冠脉病变发生的一个独立危险因素。Hcy与Gensini积分之间相关性不显著 (r=0 15 7,P =0 10 2 )。Hcy不是冠脉病变严重程度的显著影响因素(P =0 931)。结论 Hcy是冠状动脉发生病变的独立危险因素 。

Objective To investigate the relationship between of the serum homocysteine (Hcy) level and the occurrence and severity of diseased coronary arteries in patients. Methods The total serum Hcy content was determined in sixty-seven patients with diseased coronary arteries and forty-three normal subjects. They were all subjected to coronary artery angiography for evaluation. Using the Gensini's scoring system the degree of severity of of pathology the coronary arteries were assessed. Other risk factors were analyzed in addition to Hcy and Gemini's scores. Results The total serum level of Hcy in patients with diseased coronary artery was significantly higher compared with the normal controls (P<0.05). Using logistic regression analysis, Hcy was independently related to the incidence of coronary artery disease. However, using a spearman analysis Hcy had no significant correlation with the severity of the diseased coronary artery (r=0.157,P=0.102). Robust regression showed Hcy was not a significant risk factor for Gemini's scores (P=0.931). Conclusions Hcy is an independent risk factor for the occurrence of coronary artery disease, but it has no significant association with the severity of the disease.