成年妇女阴道酵母样真菌感染的调查分析

Investigation of Vaginal Candida Infection of Adult Female

目的 对真菌性阴道炎进行准确诊断 ,从而对症治疗避免滥用抗生素并节约开支 ,给临床治疗提供合理用药的依据。方法 对自 2 0 0 2年 1 1月 1日至 2 0 0 3年 1 1月 1日到该院就诊的 5 4 1例妇女阴道拭子进行霉菌培养和鉴定 ,阳性标本进行药物敏感性试验。结果 共检测 5 4 1例病人标本 ,如果把任何一个鉴定为真菌的结果均视为阳性结果 ,阳性例数为 97例 ,总阳性率为 1 7.9%。白色假丝酵母菌占第一位 ,检出率为 1 4.0 % ,占阳性标本的 78.4%。常规用药药敏结果分析 :对于阴道的真菌感染 ,制霉菌素 (NYS)和咪康唑 (MIZ)的敏感率为 1 0 0 % ,其次为两性霉素 B(AMB) 98.97% ;5 -氟胞嘧啶 (5 - FC) 92 .78% ;酮康唑(KET) 89.69% ;益康唑 (ECO) 86.6%。结论 白色假丝酵母菌是阴道真菌感染的主要病源菌 ;对阴道真菌感染 ,制霉菌素 (NYS)和咪康唑 (MIZ)

Objective To investigate the fungus infection condition on adult female vagina;look for the most suitable anti-fungal drugs;provide evidence for anti-fungal drugs treatment.Methods 541 vaginal swabs were collected from Nov 1,2002 to Nov 1,2003 at Beijing United Family Hospital.Fungal culture,identification and susceptibility tests were done.Results There were 97 cases of candida infection in 541 samples.The positive rate was 17.9%.Among them candida albicans were the main pathogenic fungi.The positive rate was 14.0%.The susceptibility tests showed that sensitivity rate for anti-fungal drug were:Nystatin and Miconazole(100%),Amphotencin(98.97%);Flucytosine(92.78%);Ketoconazole(89.69%);Econazole(86.6%).Conclusion Candida albicans was the main pathogenic for fungal vaginosis;Nystatin and Miconazole were effective drug for experience choice.