育龄期妇女体内有机污染物成分的鉴定与分析

Identification and Analysis of Organic Pollutants in Child-Bearing Age Women Body

目的了解育龄期妇女体内有机物污染状况,评估其对妇女及后代健康的危害。方法选择年龄在23～32岁健康妇女8人,分别采集全血及尿样,经正己烷萃取有机物后,利用气相色谱-质谱(GC-MS)仪进行有机物的定性分析。结果血样中共检出有机物34种,人均(8.63±5.01)种;检出频率较高的为邻苯二甲酸二丁酯(100%)、14-β-孕激素(75.0%)等。尿样中共检出有机物39种,人均(11.63±1.30)种,检出频率较高的为邻苯二甲酸二丁酯(100%)、HAHNFETT(100%)、14-β-孕激素(87.5%)、二十二烷(87.5%)、邻苯二甲酸二异丁酯(75.0%)等。在所检出的化合物中部分为环境有毒污染物。结论育龄期妇女体内存在环境污染物,其中邻苯二甲酸酯类物质检出频率较高。它们对人群健康的潜在危害应当引起重视。

Objective To investigate the exposure levels of organic pollutants in child-bearing age women body. Methods The blood and urine specimens were collected simultaneously from each of 8 health women, aged 23-32 years, the organics were extracted with hexane and determined qualitatively by gas chromatography-mass spectrometer (GC-MS) for each specimen. Results In blood, 34 kinds of organic compounds had been detected , at average of (8.63±5.01 )kinds per person. Di-n-butyl phthalate (100%) and 14-bate-H-pregna (75.0%) revealed the highest detectable rates. In urine, 39 kinds of organic compounds had been identified, at average of (10.63±1.30) kinds per person, di-n-butyl phthalate(100%), HANFETT(100%), 14-bate-H-pregna(87.5%), docosane (87.5%), di-isobutyl phthalate(75.0%) were the chemicals noticed more frequently. Some kinds of these identified organics compounds were environmental toxic pollutants. Conclusion This study suggested that toxic organic pollutants had existed in child-bearing age women body, phthalic acid esters were the chemicals checked out more frequently. Their potential adverse health effects on women and offspring should be paid highly attention to.