腹腔注射治疗肝硬化腹水的临床研究

Clinical Observation of Abdominocentesis Therapy for Hepatocirrhosis and Ascites

目的 观察腹腔注射多巴胺、速尿、抗生素治疗肝硬化腹水的疗效 ,并与常规治疗组比较。方法 1 0 6例患者随机分为A、B两组 ,B组 5 2例 ,给予常规治疗方法 :包括限制水钠摄入、利尿、扩容、输注白蛋白、维持肠道微生态平衡及支持疗法。A组 5 4例在常规治疗基础上 (但不限钠盐 )加用多巴胺针 2 0mg、速尿针 4 0～ 80mg、头孢塞肟钠针 1g或丁胺卡那针 0 2g腹腔注射 ,每日 1次 ,3天后改为隔日 1次 ,直至腹水消退。结果 A组显效率 6 1 1 % ,有效率 33 3% ,B组显效率 36 5 % ,有效率 4 8 0 % ,A组明显优于B组 ,有显著差异 (P <0 0 5 )。结论 腹腔注射多巴胺、速尿。

Objective To observe the effects of the injection of Dopamine Furosemide and antibiotics in abdominal cavity for curing ascites while comparing to the effects of conventional therapy.Methods 106 patients was divided into group A and B randomly.52 in group B were treated with conventional therapy: limiting the absorption of water and sodium, diuresis、 expanding blood capacity、 injecting albumin、 maintaining the equilibrium of the microecosystem in intestines and supporting therapy. 54 patients in Group A were treated not only with the conventional therapy (but not limit the sodium) but also with 20 mg Dopamine injection,40～80mg Furosemide injection and 1g Cefotaxime injection or 0.2g Amikacin injection in abdominal cavity once a day and after three days once every two days until ascites vanished.Results In group A responsive effectiveness rate is 61 1%, and effectiveness rate is 33 3%; in group B responisve effectiveness rate is 36 5% and effectiveness rate is 48 0%. So the results in group A was apparently better than those in group B and there is obvious difference (P<0 05) .Conclusion The injection of Dopamine、 Furosemide and antibiotics in abdominal cavity can substantially improve the absorption of ascites.