低剂量汞对镉诱导大鼠子宫增重作用的影响

Research on the affect of mercury chloride on estrogenic effect of cadmium chloride

目的 了解HgCl2 对CdCl2 雌激素样作用的影响。方法 以HgCl2 、CdCl2 等为受试物 ,设不同剂量的组合检测其对去卵巢SD大鼠子宫的诱导增重作用 ,并以E2 为阳性对照。结果 1.0 0mg/kgHgCl2 和 2 .0 0mg/kgCdCl2 均可诱导去卵巢SD大鼠子宫明显增重 ,与阴性对照组相比差异有统计学意义 (P <0 .0 5 )。 0 .0 4mg/kgHgCl2 与不同剂量的CdCl2 联合染毒 ,可致去卵巢SD雌性大鼠子宫明显增重 ,与阴性对照组相比 ,不仅高剂量组差异有统计学意义 (P <0 .0 5 ) ,低剂量也有统计学意义 (P<0 .0 5 )。结论 低剂量HgCl2 对CdCl2 具有雌激素样的联合作用。

Objective To evalute the affect of mercury chloride on estrogenic effect of cadmium chloride. Methods We observed the effect of environmental estrogen by examining the effects of mercury chloride cadmium chloride (cadmium chloride+mercury chloride)、E 2 on the growth of the uterus of ovariectomized SD rats. Results It was suggested that 1.00mg/Kg mercury chloride、2.00mg/Kg cadmium chloride、(0.04+2.00)mg/Kg (mercury chloride+cadmium chloride) and (0.04+0.08)mg/Kg(mercury chlorid+cadmium chloride e)cand stimulate the growth of the uterus of ovariectomized SD rats. Conclusions Mercury chloride has affect on on estrogenic effect of cadmium chloride.