瘦素 胰岛素与妊娠期高血压疾病发病的关系

Relationship between leptin,insulin and hypertensive disorder complicating pregnancy

目的 探讨瘦素、胰岛素在妊娠期高血压疾病 (妊高征 )发病中的意义及相互关系。方法 2 0 0 1年 1月至 2 0 0 2年 12月 ,采用放射免疫法对 30例妊娠期高血压疾病患者 ,30例正常孕妇的血清瘦素、胰岛素进行测定 ,并测定孕妇血压及尿蛋白含量 ,同时测定其新生儿脐血清瘦素、胰岛素水平。结果 妊娠期高血压疾病患者血清瘦素与胰岛素水平均明显高于对照组 (P <0 0 1)。妊娠期高血压疾病患者血清瘦素与胰岛素呈正相关(r =0 4 6 )。妊娠期高血压疾病患者血清瘦素水平与尿蛋白含量呈正相关 (P <0 0 5 ) ,与血压无明显相关性 (P>0 0 5 )。结论 孕妇血清瘦素水平可作为反映妊娠期高血压疾病患者胎盘缺氧严重程度即病情严重程度的潜在临床指标。妊娠期高血压疾病患者血清胰岛素与瘦素水平呈正相关 ,两者共同参与妊娠期高血压疾病的发病。

Objective To study the significance of leptin and insulin in the development of hypertensive disorder complicating pregnancy.Methods During January 2001 and December 2002,radioimmunoassay was used to test the level of serum leptin and insulin in 30 patients with hypertensive disorder complicating pregnancy and 30 normal pregnant women.Their blood pressure and the content of urinery protein were also measured,as well as their neonates umbilical serum leptin and insulin level.Results Levels of leptin and insulin in the group of hypertensive disorder complicating pregnancy were significantly higher than those of normal pregnant women(P<0.01).Leptin level was positively related to insulin(r0.46),and the degree of urinary protein(P<0.05),but not to the blood pressure (P>0.05).Conclusion Serum leptin level can predict the severity of hypertensive disorder complicating pregnancy.Serum leptin and insulin may play a role in the development of hypertensive disorder complicating pregnancy.