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Gefitinib治疗晚期细支气管肺泡癌 被引量:3

Gefitinib for Advanced Bronchioloalveolar Carcinoma
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摘要 本院3例晚期重症支气管肺泡癌患者经新型靶向制剂表皮生长因子酪氨酸激酶抑制剂Gefitinib(Iressa)治疗取得显著疗效,提示Gefitinib可有效治疗晚期经含有铂类和/或泰索帝(TXT)治疗失败的细支气管肺泡癌及一般情况差、无法化疗的患者。 We described 3 cases of advanced bronchioloalveolar carcinoma(BAC), in whom once-daily treatment with 250 mg Gefitinib(Iressa)demonstrated remarkable antitumor effects. Gefitinib may produce dramatic clinical responses when admi-nistered to patients with poor performance status who had received heavy platinum/docetaxel-based prior chemotherapy.
出处 《中国医学科学院学报》 CAS CSCD 北大核心 2004年第3期340-343,共4页 Acta Academiae Medicinae Sinicae
关键词 表皮生长因子受体肺肿瘤 化学治疗 epidermal growth factor receptor pulmonary neoplasma chemotherapy
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  • 1World Health Organization. The World Health Organization histological typing of lung tumours. 2nd. Am J Clin Pathol,1982, 77(2):123-136
  • 2Feldman ER, Eagan RT, Schaid DJ, et al. Matastatic bronchioloalveolar carcinoma and metaststic adenocarcinoma of the lung: comparison of clinical manifestation, chemotherapeutic responses, and prognosis. Mayo Clin Proc, 1992, 67:27-32
  • 3Kris MG, Herbs R, Rischin D, et al. Objective regressions in non-small cell lung cancer patients treated in phase Ⅰtrails of oral ZD 1839 (IRESSA), a selective tyrosine kinase inhibitor that blocks the epidermal growth factor receptor (EGFR). Lung Cancer
  • 4Fukuoka M, Yano S, Giaccone G, et al. Final results from a phase Ⅱ trial of GEFITNIB (‘Ir essa') for patients with advanced non-small-cell lung cancer (IDEAL 1). Proc Am Soc Clin Oncol, 2002, 21:1188a
  • 5Douillard JY, Giaccone G, Horai T, et al. Improvement in symptoms and quality of life for advanced non-smallcell lung cancer patients received GEFITNIB (Iressa) in IDEAL 2. Proc Am Soc Clin Oncol, 2002, 21:1189a
  • 6Kris M, Natale R, Herbst R, et al. Efficacy of gefitinib,an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer: a randomized trial. JAMA, 2003, 290(16):2149-2158
  • 7Natale RB, Skarin AT, Maddox AM, et al. Improvement in disease-related symptoms and quality of life in patients with advanced non-small-cell lung cancer (NSCLC) treated with GEFITNIB (‘Iressa') (IDEAL 1). Proc Am Soc Clin Oncol, 2002, 21:1167a
  • 8Negoro S, Nakagawa K, Fukuoka M, et al. Final results of a phase Ⅰ intermittent dose-escalation trail of ZD 1839(‘Ir essa') in Japanese patients with various solid tumors.Proc Am Soc Clin Oncol, 2001, 20:324a
  • 9Baselga J. Yano S, Giaccone G, et al. Initial results from a phase trial of GEFITNIB (‘Iressa') as second- and thirdline monotherapy for patients with advanced non-small-cell lung cancer (IDEAL 1). Clin Cancer Res, 2001, 7:3781s
  • 10Chang GC, Yang TY, Wang NS, et al. Successful treatment of multifocal bronchioloalveolar cell carcinoma with ZD1839(Iressa) in two patients. J Formos Med Assoc, 2003, 102:407-411

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