鼻咽癌常规适形放疗与普通放疗的临床研究

Comparison of conventional conformal radiotherapy with conventional radiotherapy in eighty-eight patients with nasopharyngeal carcinoma.

目的 探讨普通放疗与常规适形放疗在鼻咽癌治疗中的近期疗效及放疗不良反应。方法 2 7例常规适形放疗 (治疗组 )患者采用英国菲利蒲公司SL 75直线加速器和SLi型直线加速器 ,以整体适形挡铅方法实施不规则野等中心照射的常规适形治疗。对照组 6 1例采用面颈联合野等常规治疗。结果 局控率 :常规适形放疗组总有效率为 96 .3% (2 6 / 2 7)。普通放疗组总有效率为 90 .2 % (5 5 / 6 1 )。两组之间总有效率无明显差异 (P >0 .0 5 )。但完全缓解率常规适形放疗组显著高于对照组 (P <0 .0 1 )。不良反应如 :口咽黏膜反应、消化道反应、骨髓抑制、急性腮腺反应及口干等症状 ,适形放疗组均好于对照组。两组比较有显著差异 (P <0 .0 1 )。结论 采用常规适形放疗在保证局控率同时 ,可减轻放疗不良反应 。

Objective To evaluate response to radiotherapy and its side effects in NPC patients treated with conventional conformal radiotherapy(CCRT) or conventional radiotherapy.Methods Eighty eight patients with nasopharyngeal carcinoma(NPC) were enrolled into this clinical study.The CCRT was finished with philliph linear accelerator and isocentric technique,and the conventional radiotherapy was performed as usual.Results The CCRT group had a markedly higher complete response rate( P <0.01)although there was no significant difference of local control rates between CCRT group(26/27,96.3%) and conventional radiotherapy group(55/61,90.2%).Significant difference was also found between these two groups in terms of side effects such as acute oral mucusitis,nausea,vomiting,bone marrow inhibition and acute parotitis( P <0.01).Conclusion Compared with conventional radiotherapy,slighter radioactive injuries,higher complete response rate,and better quality of life can be achieved by CCRT in NPC patients.