参麦注射液对豚鼠缺氧型心搏骤停心肺复苏的影响

Experimental Study on Effect of Shenmai Injection(参麦注射液) for the Resuscitation of Asphyxial Cardiopulmonary Arrest in Guinea pigs

目的 观察参麦注射液(SM)对缺氧型心搏骤停(CA)豚鼠模型心肺复苏(CPR)成功后自主循环的影响。方法 将豚鼠随机分为SM组和生理盐水(NS)组,腹腔注射SM、NS30min后,采用夹闭气管窒息法复制CA豚鼠模型,监测夹管前后豚鼠的心电图变化,并记录开始CPR至自主循环恢复时间和自主循环维持时间。结果 两组CPR成功率相近;SM组循环恢复时间短于NS组,循环维持时间长于NS组。结论 SM可缩短缺氧型CA豚鼠型CPR的自主循环恢复时间,延长CPR成功后的循环持续时间,但对豚鼠CPR成功率无明显影响,说明SM对促进CA的自主循环恢复和提高恢复后自主循环的稳定性具有积极意义。

Objective: To study the influence of Shenmai Injection(参麦注射液,SM)on the cardiopulmonary resuseitation(CPR) of the guinea pigs' hypoxic cardiopulmonary arrest(CA) model. Methods: coventional (CV) guinea pig examples were randomly divided into two groups, the SM group and the normal saline(NS) group. After injecting the SM or NS 30 minutes, clipped the trachea of the CA model, monitored the guinea pigs' electrocardiogram, recorded the recovering time and the maintaining time of the independent circulation. Results: There was no difference of the CPR success rate between the two groups. But there was obvious difference of the independent circulation's recovering time and maintaining time. Conclusion: SM can shorten independent circulation's recovering time of the guinea pig's hypoxic cardiopulmonary arrest model in the CPR, and prolong the independent circulation's main taining time. But it has no influence on the CPR's success rate. So the SM has the positive meaning on the impoving of CA circulation's recovery and maintenance.