人参皂苷Rg_2对麻醉犬急性心源性休克血流动力学和氧代谢的影响

Effects of ginsenoside Rg_2 on hemodynamics and oxygen metabolism in narco-canine with acute cardiogenic shock

目的 :观察人参皂苷 Rg2 (ginsenoside Rg2 )对犬急性心源性休克血流动力学和氧代谢的影响。方法 :结扎犬冠状动脉左前降支 (L AD)复制心源性休克模型 ,观察人参皂苷 Rg2 (2和 1m g· kg- 1 )对麻醉犬血流动力学和氧代谢各项指标的作用。结果 :人参皂苷 Rg2 可升高平均血压 (MBP)、左室内压 (L VSP)、± dp/dtmax和心排出量 (CO) ,降低心肌耗氧指数、心肌氧摄取率。结论 :人参皂苷 Rg2 对犬急性心源性休克具有一定的治疗作用。

Objective To investigate the effects of ginsenoside Rg 2 on hemodynamics and oxygen metabolism in narco-canine with acute cardiogenic shock. Methods Model of acute cardiogenic shock was made by ligating left anterior descending branch of coronary artery(LAD). Hemodynamics and oxygen metabolism in narco-canine were observed after administrated with 2 and 1 mg·kg -1 ginsenoside Rg 2. Results Ginsenoside Rg 2 increased mean blood pressure (MBP),left ventricular systolic pressure (LVSP),±dp/dt max,and cardiac output (CO), remarkably, and reduced the exponent of oxygen consuming of myocardium and the rate of oxygen intake of myocardium compared with control group. Conclusion Ginsenoside Rg 2 has therapeutical effect on acute cardiogenic shock in canine.