异丙酚在无抽搐电休克治疗麻醉中的应用

Application of Propofol Anesthesia in Modified Electroconvulsive Therapy

目的 :研究异丙酚在无抽搐电休克治疗 (MECT)麻醉中的应用效果及安全性。方法 :34例首次住院的精神分裂症患者随机分为异丙酚组和硫喷妥钠组 ,每组 17例 ,每例完成 1个疗程 6次MECT治疗 ,每组完成 10 2人次治疗 (n =10 2 )。每次治疗时 ,异丙酚组给予异丙酚静脉麻醉 ,硫喷妥钠组给予硫喷妥钠静脉麻醉 ,全麻诱导后皆静注琥珀酰胆碱 ,待肌肉松弛后行MECT治疗。全程监测患者心电图、血氧饱和度、血压、心率、脉搏 ,并观察记录自主呼吸恢复时间。苏醒时间和不良反应 ,进行前瞻性研究。结果 :与硫喷妥钠组相比 ,异丙酚组自主呼吸恢复快 ,苏醒快 ,无咳嗽 ,呃逆 ,呕吐等不良反应 ,两组差异显著。而异丙酚组注射点疼痛发生率显著高于硫喷妥钠组。结论 :在MECT中应用异丙酚静脉麻醉是一种更安全、有效的方法。

Objective: To research the effect and safety in propofol anesthesia in modified electroconvulsive therapy for patients. Methods: Thirty four schizophrenic patients who were first admitted in our hospital were randomly divided into two groups:propofol group (17 cases) and thiopentone group (17 cases) .Everyone was treated with modified electroconvulsive therapy 6 times,and every group had the therapy 102 times. During the therapy,the propofol group was anesthetized with propofol,the thiopentone group was anesthetized with thiopentone. Patients'response,time to catch breath,time to revive,BP,HR and sPO_2 were observed. Results: Time to catch breath and to revive was shorter in propofol group than those in thiopentone group ( P <0.05).Compared with thiopentone group,side effects of patients were reduced in propofol group ( P <0.05). Conclusion: Propofol anesthesia in modified electroconvulsive therapy for patients is effective and safe.