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降血脂药物的研究进展 被引量:36

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摘要 以胆固醇和甘油三酯水平过高或伴有血清高密度脂蛋白胆固醇水平过低为特征的高脂血症是引起动脉粥样硬化进而导致冠心病、高血压和脑血管疾病的主要原因 ,因而开发有效的降血脂药物已成为全球关注的课题。本文从抑制胆固醇的吸收、体内合成及促进胆固醇与甘油三酯的体内代谢的角度出发 ,介绍了近年来化学合成和天然来源的降血脂药物。
作者 王海勇 王林
出处 《国外医学(药学分册)》 2004年第3期160-166,共7页 Foreign Medical Sciences(Section of Pharmarcy)
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  • 1Miller M, Cosgrove B, Havas S. Update on the role of triglycerides as a risk factor for coronary heart disease[J].Curr Atheroscler Rep, 2002, 4(6) :414 - 418.
  • 2Instull W Jr, Toth P, Mullican W, et al. Effectiveness of colesevelam hydrochloride in decreasing LDL cholesterol in patients with primary hypercholesterolemia: a 24-week randomized controlled trial[ J ]. Mayo Clin Proc, 2001, 76(10) :971 - 982.
  • 3Weston C. The place of ezetimibe in clinical practice[J].Hosp Med, 2003, 64(8) :473 -478.
  • 4Kerzner B, Corbelli J, Sharp S, et al. Efficacy and safety of ezetimibe coadministered with lovastatin in primary hypercholesterolemia[J]. Am J Cardiol, 2003, 91 (4):418 -424.
  • 5Stein EA. An investigative look: selective cholesterol absorption inhibitors - embarking on a new standard of care[J]. Am L Manag Care, 2002, 8(2 Suppl):S36 - S39.
  • 6Olsson AG, Istad H, Luurila O, et al. Effects of rosuvastatin and atorvastatin compared over 52 weeks of treatment in patients with hypercholesterolemia[ J]. Am Heart J, 2002,144(6): 1044 - 1051.
  • 7Martin PD, Mitchell PD, Schneck DW. Pharmacodynamic effects and pharmacokinetics of a new HMG-CoA reductase inhibitor, rosuvastatin, after morning or evening administration in healthy volunteers[ J]. Br J Clin Pharmacol, 2002,54(5) :472 - 477.
  • 8Saito Y, Yamada N, Teramoto T, et al. A randomized,double-blind trial comparing the efficacy and safety of pitavastatin versus pravastatin in patients with primary hypercholesterolemia[ J ]. Atherosclerosis, 2002, 162 (2):373 - 379.
  • 9Aoki T, Yamazaki H, Tamaki T, et al. Triglyceride-lowering effect of pitavastatin in a guinea pig model of postprandial lipemia[J]. Arzneimittelforschung, 2003, 53(3):154-158.
  • 10Bolego C, Poli A, Cignarella A, et al. Novel statins: pharmacolngical and clinical results[J]. Cardiovasc Drugs Ther,2002, 16(3) :251 - 257.

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