足月产小于胎龄儿孕妇危险因素病例-对照研究

A case-control study of risk factors of low birth weight at term

目的 探索影响胎儿出生体重的危险因素。方法 采用 1∶1匹配的病例对照研究方法 ,收集了足月产小于胎龄儿 (SGA)及其对照共 1 5 5对。应用条件Logistic回归分析方法和相加模型对危险因素及其交互作用进行分析。结果 产妇孕前体重低 (≤ 5 2kg)、孕期体重增加少 (≤ 1 6kg)、被动吸烟和喝茶、孕期及怀孕之前 3个月内进行过染发、烫发或油、配偶身高低 (≤ 1 73cm)以及产妇体重指数大 (≥ 1 9)等与SGA的发生有显著性关联 (P <0 0 5 ) ,在调整了其他危险因素后 ,OR分别为 2 0 8、2 83、3 4 2、2 72、5 6 7、2 92和 0 4 1 ,其中产妇孕前体重低与孕期体重增加少、孕期及怀孕之前 3个月内进行过染发、烫发或油、配偶身高低和孕期被动吸烟之间存在正交互作用。结论 产妇孕前体重低 ,孕期体重增加少、被动吸烟和喝茶、孕期及怀孕之前 3个月内进行染发烫发或油以及配偶身高低等是SGA的危险因素 。

Objective To analyze the risk factors of low birth weight, the authors conducted a matched case control study. Methods 155 women which infants were singleton term SGA cases and 155 with singleton term non SGA controls were interviewed. Cases and controls were matched by infant sex and maternal age. Analyses were performed by conditional logistic regression. Results Low prepregnancy weight(≤52kg), low weight gain(≤16kg), passive smoking and drinking tea during pregnancy, dying hair, marcel or curium oil three month before pregnancy and during pregnancy, low husband height(≤173cm), and maternal BMI (≥19) were associated with risk of term SGA. The odds ratio of those risk factors were 2 08, 2 83, 3 07, 2 94, 3 42, 2 72, 5 67, 2 92 and 0 41 respectively.Conclusion It was also found significant positive interactions between low maternal weight and low weight gain, and dying hair, marcel or curium oil three month before pregnancy and during pregnancy, and low husband's height, and passive smoking during pregnancy.