塞来考昔对女性卵巢功能的影响

Influence of celecoxib on ovary function

目的 :观察塞来考昔 (celecoxib)对女性卵巢功能的影响。方法 :5 6例痛经病人分为 2组 ,A组给予塞来考昔治疗 1wk ,B组给予山莨菪碱治疗1wk ,采用对照的方法进行临床试验。结果 :塞来考昔对治疗前后病人性激素 (PRL ,E2 ,LH ,FSH)水平无明显影响 (P >0 .0 5 ) ,与山莨菪碱治疗组比较无显著差异 (P >0 .0 5 ) ,其对滤泡直径的影响与山莨菪碱治疗组比较亦无显著差异 [(2 0 .1±s 1.3)mmvs(19.4± 1.1)mm ,P >0 .0 5 ]。结论 :短期使用塞来考昔对女性卵巢功能可能无明显影响。

AIM: To investigate the influence of celecoxib therapy on ovary function. METHODS: Fifty-six women with menstrual pain were divided into two groups (group A and group B),with group A treated with celecoxib and group B with anisodamine for 1 wk,sex hormone concentrations and the diameter of ovary follicle were compared. RESULTS: Sex hormone concentrations (PRL,E_2,LH and FSH)do not be affected before and after treatment with celecoxib ( P >0.05)and have no significant difference compared with anisodamine treating. The diameter of ovary follicle in group A do not be changed compared with group B( P >0.05). CONCLUSION: Short-term using of celecoxib do not affects ovary function.