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嗜酸粒细胞与支气管哮喘的治疗 被引量：2

Eosinophils and the therapy of bronchial asthma
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摘要 支气管哮喘是由嗜酸粒细胞(EOS)浸润为主的气道慢性炎症。白细胞介素-5(IL-5)和嗜酸粒细胞特异性趋化因子(eotaxin)均选择性作用于EOS,在哮喘发病机制中起重要作用。抗IL-5单克隆抗体、调控IL-5基因转录、可溶性IL-5受体α链、编码IL-5的DNA疫苗、抗eotaxin的受体CCR3抗体以及针对IL-5和eotaxin联合治疗哮喘的研究已经取得了一定的进展,开发有效的药物或治疗方法从多个层面对EOS进行干预的联合治疗,将是今后研究的重要内容之一。
作者 金蕊 杨莉
机构地区 东南大学附属中大医院儿科
出处 《国外医学（儿科学分册）》 2004年第4期187-189,共3页 Foreign Medical Sciences（Section of Pediatrics)
关键词 嗜酸性细胞 白细胞介素5 趋化因子 嗜酸细胞 哮喘
分类号 R562.25 [医药卫生—呼吸系统]
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参考文献18

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  • 2Jahnsen FL, Haye R, Gran E, et al. Glucocorticosteriods inhibit mRNA expression for eotaxin, eotaxin-2, and monocyte-chemotactic protein-4 in human airway inflammation with eosinophila[ J] .J Immunol, 1999,163(3):1545-1551.
  • 3White JR, Lee JM, Dede K, et al. Identification of potent, selective nonpeptide CC chemokine receptor-3 antagonist that inhibits eotaxin-, eotaxin2-,and monocyte chemotactic protein-4-induced eosinophil migration[J]. J Biol Chem,2000,275(47) :36626-36631.
  • 4Shahabuddin S, Ponath P, Schleimer RP. Migration of eosinophlls across endothelial cell monolayers: interactions among IL-5, endothelial-activating cytokines, and C-C chemokines[ J]. J Immunool, 2000, 164(7): 3847-3854.
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国外医学（儿科学分册）
2004年 第4期

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