CpG寡聚脱氧核苷酸在灵长类动物中免疫调节活性的研究进展

Research progress on immunoregulatory activity of CpG oligonucleotides in primates

包含CpG基序的寡聚脱氧核苷酸 (ODN)具有类似于微生物DNA激活内在免疫系统的能力 ,可提高适应性免疫力而抑制传染性生物的早期传播。CpGODN在疫苗佐剂的设计以及哮喘、过敏、传染病和癌症的治疗中显示出良好的应用前景。由于CpG识别体系在进化中出现的种间差异 ,在啮齿类动物中表现出最强活性的CpGODN却无法有效地刺激灵长类动物产生免疫应答。已有大量证据表明CpGODN在小鼠中具有治疗活性 ,而其在灵长类动物中作用的研究仍需继续深入。现就作用于灵长类动物的CpGODN的分类、作用机制和其作为疫苗佐剂与免疫保护剂以及在癌症。

Oligodeoxynucleotides(ODN) containing CpG motifs possess the ability of microbial DNA to activate the innate immune system,which limits the early spread of infectious organisms while promoting the development of adaptive immunity. CpG ODN are of promise as vaccine adjuvants and agents in the treatment of asthma, allergy, infection, and cancer. Due to evolutionary divergence in CpG recognition between species, CpG ODN active in rodents,are poorly immunostimulatory in primates. Thus, evidence that CpG ODN have therapeutic activity in mice must be confirmed in primates.In this paper,two distinct types of CpG ODN and their mode of actions will be introduced and the literature documenting their ability to act as vaccine adjuvants and immunoprotective agents in primates and in the treatment of diseases such as cancer,allergy and asthma will be reviewed.