移植物抗肿瘤效应及其在实体瘤治疗中的意义

Graft-versus-tumor effect and its significance in the treatment of solid tumor

异基因造血干细胞移植 (Allo HSCT)因具有独特的移植物抗恶性病效应常用来治疗某些恶性血液病 ,近年来Allo HSCT在临床上尝试性地用来治疗某些实体瘤并取得了一定的疗效 ,现就Allo

Allogeneic hematopoietic stem cell transplantation(Allo-HSCT) has proved to have a unique immune-mediated antitumor effect in patients with hematologic malignancies. However,recently more investigators have come to recognize that antineoplastic effect mediated by immunopotent donor T-cells transplanted with the stem cell allograft can be induced against solid malignancies and achieved some therapeutic effect.This article reviews the graft-versus-tumor effect and its immunotherapeutic mechanism to investigate the potential of allogeneic immunotherapy for treating solid tumor.