高原长期饮酒者血清纤维化指标的改变及临床意义

Clinical value of assay of serum fibrosis markers for chronic drinkers in plateau

目的 探讨血清纤维化指标在高原长期饮酒者中的变化及临床意义。方法 将 4 8例高原长期饮酒患者根据饮酒时间分为A、B、C共 3组 ,采用放射免疫法检测 3组患者和 30例对照组血清透明质酸 (HA)、Ⅲ型前胶原氨基端肽 (PⅢP)、层黏连蛋白 (LN)、Ⅳ胶原 (CⅣ )水平 ;常规方法检测血清总胆红素 (T BIL)、谷丙转氨酶 (ALT)、白蛋白 (ALB)浓度。结果 随着饮酒时间的增长 ,血清HA、LN、CⅣ、PⅢP浓度逐渐增加 (P <0 .0 5 ) ,且肝功能损害明显 (P <0 .0 5 )。结论 高原长期饮酒患者血清纤维化指标随着饮酒时间和量的增加而升高 。

Objective To investigate the clinical value of serum fibrosis markers for chronic drinkers in plateau. Methods Forty-eight chronic drinkers in plateau were divided into three groups (A, B, C) according to their history of drinking.The levels of serum hyaluronic acid (HA), laminin (LN), type IV collagen (CⅣ),and procollagen type Ⅲ aminoterminal peptide (PⅢP) were determined by competitive radioimmunoassay in three drinker groups and 30 normal control group.Liver function indices includling serum total bilirubin,alanine transaminase,and albumin were assayed by routine method. Results With extending history and increasing capacity of liquor consumption, serum levels of HA, LN, CⅣ, PⅢP and liver function indices in chronic drinkers in plateau were significantly elevated,compared with normal controls(P<0. 05). Conclusion Elevation of serum levels of HA, LN, CⅣ and PⅢP and liver function indices is associated with the history and capacity of liquor consumption in chronic drinkers in plateau, and can predict the different degree of hepatic fibrosis and damage to liver function.