正交设计法优选5F疤痕乳膏基质组成及制备工艺

Optimization of Base Composition and Technology for5F Scar Emulsion by Orthogonal Design

目的 :优选半边旗提取物5F疤痕乳膏基质组成及工艺。方法 :针对影响乳剂稳定性的因素 ,用正交设计法 ,以单硬脂酸甘油酯、三乙醇胺、十二烷基硫酸钠及乳化温度为可变因素 ,选用L9(34)表进行试验。结果 :最优的基质组成及工艺为单硬脂酸甘油酯6 %、三乙醇胺0 5 %、十二烷基硫酸钠0 %、乳化温度80℃。结论 :按此法制备出的乳膏符合《中国药典》

OBJECTIVE:To optimizate base material composition and technology for5F scar emulsion.METHODS:According to the factors that affect the stability of emulsion,orthogonal design method L 9 (3 4 )was used,glyceryl monostearate,triethanolamine,sodium lauryl sulfate and emulsifying temperature were selected as variable factors.RESULTS:The optimum base material composition and technology were glyceryl monostearate6%,sodium lauryl sulfate0%,triethanolamine0.5%,emulsifying temperature80℃.CONCLUSION:The5F scar emulsion prepared by this composition and technology accords with the stipulation of Chinese Pharmacopoeia(2000).