复方甘草酸苷与甘草酸二铵治疗拉米夫定停药后反跳的疗效观察

Therapeutic Effects of Compound Glycyrrhizin and Ganlixin on Relapse Following Withdrawal of Lamivudine

目的 :观察复方甘草酸苷与甘草酸二铵治疗拉米夫定停药后慢性乙型肝炎 (CHB)患者病情反跳的疗效 ,并比较其差异。方法 :将76例停用拉米夫定后CHB病情反跳的患者分为复方甘草酸苷组和甘草酸二铵组。观察和记录患者症状、体征的变化及药物不良反应 ,定期检测肝功能、HBV血清免疫学标志物、HBV -DNA定量等项目 ,随访12个月。结果 :复方甘草酸苷组与甘草酸二铵组总有效率分别为79 49 %和75 68 % ,两组间无显著性差异 (P>0 05) ;两组在AST复常方面有显著性差异 (P<0 01) ;复方甘草酸苷组显效率为69 23 % ,甘草酸二铵组显效率为48 65 % ,两组亦有显著性差异 (P<0 05)。结论 :复方甘草酸苷与甘草酸二铵治疗拉米夫定停药后CHB患者病情反跳均有明显的疗效 ,前者停药后病情反跳率低 ,疗效稳定、持久。

OBJECTIVE:To observe the therapeutic effects of compound glycyrrhizin(GL)and Ganlixin(GX)on the relapse of chronic hepatitis B(CHB)after withdrawal of Lamivudine and to compare the effect between GL and GX.METHODS:76patients with relapse of CHB after withdrawal of Lamivudine were divided into GL group and GX group.The changes of symptoms and signs as well as ADRs were observed and the liver functions,serum HBV immunological markers and HBV DNA were detected at regular intervals.Patients were followed for12months.RESULTS:The total effective rates of GL group and GX group were79.49%and75.68%respectively without significant difference(P>0.05).There was significant difference in recovery of AST between two groups(P<0.01).The excellent rates of GL and GX were69.23%and48.65%respectively with significant difference(P<0.05).CONCLUSION:Both GL and GX have obvious therapeutic effects on relapse of CHB after withdrawal of Lamivudine,however,GL shows lower relapse rate and more stable and sustained effect than GX.