住院患者服用分劈药片的利弊

The Advantages and Disvantages of Split Tablets Given to In-patients

目的 :探讨住院患者服用分劈药片的利弊。方法 :收集我院由药师分劈、住院患者常用的13种处方药片 ,每种10片 ,共260个分劈片 ,采用《美国药典》剂量单位一致性测试方法分析分劈药片的重量变异性。结果 :药片分劈后均未通过剂量单位一致性测试。药片分劈效果与外形有关 ,带有刻线的相对好一些。在分劈过程中都存在一定的剂量损耗。结论 :药片分劈导致高比率的重量变异 ,故为节省开支而分劈药片的做法仅适合于那些低毒和剂量 -反应效应曲线相对平坦的药物 ,对于那些毒性较大和剂量

OBJECTIVE:To analyse the advantages and disvantages of split tablets given to in-patients.METHODS:We collected13kinds of oral tablets(10tablets each kind and260pieces of the split tablet altogether),which were often splitted by pharmaceutists.We tested and analysed the weight variation of the split tablet on the basis of the dosage consistency metioned in the USP which is applied to the whole tablet.RESULTS:None of the13kinds of prescription drug passed the consistent testing after splitting.There was some relationship between the effect of the split tablet and its shape.It was relatively easy to break off the tablet with nick in half.The loss of dosage inevitably occurred during the process of splitting the tablet.CONCLUSION:Breaking off the tablet in half led to high ratio of weight variation.The modus operandi of splitting the tablet in half for saving expenses can only be applied to those drugs with low toxicities and relatively flat dose-effect curve.In the case of those drugs which bear high toxicities and steep dose-effect curve,carefulness should always be taken when applying such method.