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胱冬酶抑制剂与脑缺血 被引量：3

Caspase Inhibitor and Cerebral Ischemia
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摘要 随着人们对凋亡机制认识的加深 ,胱冬酶 (caspase)抑制剂在脑缺血中的临床价值也引起广泛关注。胱冬酶抑制剂能阻断凋亡所需的特异性蛋白酶 ,而不会产生绝大多数广谱药物的不良反应 ,且治疗窗较其他神经保护药宽。因此 ,研究胱冬酶抑制剂的前景诱人。 With the recognition of the mechanisms of apoptosis, the clinical value of caspase inhibitor in cerebral ischemia has aroused general concern. Caspase inhibitor can block the specific protease that apoptosis needs, and it cannot develop the adverse effects like most broad-spectrum drugs. In comparison with other neuroprotective agents, caspase inhibitor has a broader therapeutic window. Therefore, the prospect of research into the caspase inhibitor is attractive.
作者 赵玉祥 刘家浩
机构地区 东南大学附属中大医院儿科
出处 《国外医学（脑血管疾病分册）》 2004年第7期544-547,共4页 Foreign Medical Sciences Cerebrovascular Diseases
关键词 胱冬酶抑制剂 脑缺血 细胞死亡 作用机制 分类 caspase inhibitor ■ cerebral ischemia ■ acting mechanism
分类号 R743.3 [医药卫生—神经病学与精神病学]
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参考文献18

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同被引文献20

  • 1杨渊,张苏明,方思羽,张旻,江红,许康,常履华.半胱氨蛋白水解酶的激活在脑缺血再灌流损伤中的作用[J].中华医学杂志,2004,84(12):1035-1037. 被引量：3
  • 2武祺,李欣.辛伐他汀对脑缺血-再灌注大鼠神经细胞的保护作用[J].中国脑血管病杂志,2007,4(9):410-413. 被引量：6
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  • 5Yaguchi T, Fujikawa H, Nishizaki T. Linoleic acid derivative DCP- LA protects neurons from oxidative stress-induced apoptosis by in- hibiting caspase-3/-9 activation [ J ]. Nem'ochem Res, 2010, 35 (5) :712 -7.
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引证文献3

二级引证文献14

国外医学（脑血管疾病分册）
2004年 第7期

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