RNAi及其在抗肿瘤中的应用
被引量:2
RNA interference and its prospect in antitumour
摘要
RNA干扰 (RNAi)作用是生物界普遍存在的一种进化上高度保守的现象 ,是一种研究基因功能的新方法。肿瘤是多基因疾病 ,RNAi为肿瘤的基因治疗提供新的思路 ,通过RNAi抑制癌基因的表达可能成为一种新的癌症基因治疗策略。现综述RNAi的作用机制、特点以及在抗肿瘤中应用的研究展望。
出处
《国外医学(肿瘤学分册)》
2004年第7期492-495,共4页
Foreign Medical Sciences (Cancer Section)
参考文献28
-
1Hammond SM, Bernstein E, Beach D, et al. An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells. Nature, 2000, 404 (6775): 293-296.
-
2Fire A, Xu S, Montgomery MK, et al. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature, 1998,391(6669) :806-811.
-
3Scherr M, Morgan MA, Eder M. Gene silencing mediated by small interfering RNAs in mammalian ceils. Curr Med Chem, 2003, 10( 3 ): 245 -256.
-
4Elbashir SM, Harborth J, Lendeckel W, et al. Duplexes of 21-nuckeotide RNAs mediate RNA interference in cultured mammalian cells. Nature, 2001,411(6836): 494-498.
-
5Bemstein E, Caudy AA, Hammond SM, et al. Role for a bidentate ribonuclease in the initiation step of RNA interference. Nature,2001, 409(6818): 363-366.
-
6Nicholson RH, Nicholson AW. Molecular characterization of a mouse cDNA encoding Dicer, a ribonuclease Ⅲ ortholog involved inRNA interference. Mamm Genome, 2002,13(2) :67-73.
-
7Dalmay T, Hamilton A, Rudd S, et al. An RNA-dependent RNA polymerase gene in Arabidopsis is required for posttranscriptional gene silencing mediated by a transgene but not by a virus. Cell,2000,101 (5) :543-553.
-
8Cogoni C, Macino G. Gene silencing in Neurospora crassa requires a protein homologous to RNA-dependent RNA polymerase. Nature,1999,399(6732): 166-169.
-
9Nykanen A, Haley B, Zamore PD. ATP requirements and small interfering RNA structure in RNA interference pathway. Cell, 2001,107(3) :309-321.
-
10Zamore PD, Tuschl T, Sharp PA, et al. RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals. Cell, 2000,101(1) :25-33.
同被引文献23
-
1肖翠英,张思仲.RNA干扰研究的新进展[J].医学分子生物学杂志,2004,1(2):104-106. 被引量:2
-
2刘苏虎,张镁,张王刚.在哺乳动物细胞中用于表达干扰RNA的启动子[J].医学分子生物学杂志,2004,1(3):175-177. 被引量:6
-
3李力,张令强,贺福初.RNA干扰应用新进展[J].医学分子生物学杂志,2004,1(4):224-226. 被引量:3
-
4邓娟,梁国栋.RNA干扰技术抑制病毒复制的研究进展[J].医学分子生物学杂志,2004,1(4):227-230. 被引量:2
-
5李新平,张学光.RNA干扰技术在免疫学研究中的应用[J].现代免疫学,2005,25(2):174-176. 被引量:2
-
6李新平.RNA干扰技术在药物研究中的应用[J].中国药理学通报,2005,21(4):400-403. 被引量:4
-
7Tuschl T.Expanding small RNA interference[J].Nature Biotechno-logy,2002,20(5):446-448.
-
8Aoki Y,Cioca D,Oidaira H,et al.RNA interference may be more potent than antisense RNA in human cancer cell lines[J].Clin Exp Pharmacol Physiol,2003,30(1):96-102.
-
9Sui G,Soohoo C,Affarei B,et al.A DNA vector-based RNAi technology to suppress gene expression in mammalian cells[J].Proc Natl Acad Sci USA,2002,99(8):5515-5520.
-
10Elphick MR,Kemenes G,Staras K,et al.Behavioral role for nitric oxide in chemosensory activation of feeding in a mollusc[J].J Neurosci,1995,15:7653-7664.
-
1王艳芳,苏丽萍.基因沉默的新技术:RNA干扰[J].国际检验医学杂志,2006,27(4):376-378.
-
2钱海利,林晨.RNA干扰技术的应用[J].国外医学(肿瘤学分册),2005,32(4):261-264. 被引量:1
-
3张其亮,杨述华,刘红云.干涉RNA抑制人骨肉瘤细胞PCNA表达的实验研究[J].肿瘤防治杂志,2005,12(7):511-514.
-
4王凯峰,叶胜龙.RNA干扰在肿瘤研究中的应用[J].国外医学(肿瘤学分册),2005,32(3):183-186.
-
5郁成雨,潘真,王春刚,闵锐,姚雨石,赵芳,韩玲.RNA干扰抑制RAD51基因表达对放射敏感性影响的实验研究[J].中华肿瘤防治杂志,2006,13(24):1852-1855. 被引量:3
-
6程广源.新世纪癌症治疗研究展望[J].中国社区医学,2003,9(2):53-56.
-
7刘鲁明.新世纪中医药及中西医结合抗肿瘤研究展望[J].浙江中西医结合杂志,2002,12(4):203-205. 被引量:8
-
8章静波,马静.21世纪癌症治疗研究展望[J].引进国外医药技术与设备,1999,5(6):50-54.
-
9刘秉慈.人类确定致癌物石英的研究展望[J].中华劳动卫生职业病杂志,2000,18(1):60-60. 被引量:13
-
10王堃,刘克辛,韩国柱,孔维西,徐立栋.核糖核酸干扰的发现、机制及其在医药研究中的应用[J].中国新药与临床杂志,2005,24(7):572-576. 被引量:1