3-(4-碘苯甲酰基)丙酸最佳合成条件的探讨

Determination of best synthesis condition about 3-(4-iodobenzoyl)propionic acid

目的 考察3-(4-碘苯甲酰基)丙酸的最佳合成条件。方法 通过调节高速反应溶剂、反应温度、反应时间及产品后处理方法,比较不同条件下3-(4-碘苯甲酰基)丙酸的收率。结果 以碘苯为溶剂,用沸水浴加热,反应时间3h为佳,可将3-(4-碘苯甲酰基)丙酸的收率,由14%提高到40%。结论 在本次试验确定的合成条件下3-(4-碘苯甲酰基)丙酸的收率明显提高。

Objective To determine the best synthesis condition of 3-(4-iodobenzyl)propionic acid. Methods The solvent, temperature,reaction time and method of treating semifinished product were improved and the yields of 3-(4-iodobenzoyl)propionic acid underdifferent condition were determined. Results Iodobenzene was used as solvent and the yield of 3-(4-iodobenzoyl)propionic acid wasimproved from 14% to 40% in 3 hours' reaction heated by boiled water bath.Conclusion The yields of 3-(4-iodobenzoyl)propionic acidwas obviously improved under the condition determined in this test.