大肠癌中PCNA、c-erbB2、bc1-2和P53蛋白表达与临床病理关系

Relationship between expression P53 protein, c-erbB2、PCNA and bc1-2 in colorectal cancer and clinical pathological features

目的 探讨大肠癌PCNA、c -erbB2、bc1-2和P5 3蛋白表达与临床病理的关系。方法 检测 5 2例大肠癌和正常黏膜各作为对照。用增殖细胞核抗原标记增殖指数检测其增殖活性 ;用免疫组织化学法检测c -erbB2、bc1-2和P5 3蛋白表达。结果 大肠癌组织中PCNA、c-erbB2、bc1-2、P5 3阳性率显著高于癌旁组织。阳性率分别为 82 .7%( 4 3 5 2 )、67.3 %( 3 5 5 2 )、69.2 %( 3 6 5 2 )、5 1.9%( 2 7 5 2 )。C -erbB2、Bc1-2与PCNA的阳性表达呈正相关 ,C -erbB2、Bc1-2与p5 3的阳性表达呈负相关。PCNA、C -erbB2、Bc1-2、p5 3同时阳性集中在Duck ,sC、D组。结论 PCNA、c -erbB2、bc1-2和P5 3蛋白过度表达与临床病理分期关系密切 。

Objective To study the P53 protein, c-erbB2、PCNA and bc1-2 expression and its relationship with clinical pathological features in colorectal cancer.Methods Tmmunohistochemical method was used to examine the positive rates of P53 protein, c-erbB2 and bc1-2 in 52 cases of colorectal cancer. PCNA proliferation index as proliferation activity. The normal tissues as control groups.Results Positive rate of PCNA、c-erbB2、bc1-2、P53 protein expression in colorectal cancer was higher than control groups. The positive rate is 82.7%(43/52)、67.3%(35/52)、69.2% (36/52)、51.9%(27/52) respectively. There were positive correlations between PCNA expression and C-erb B2 and Bc1-2. A negative correlation between expression of P53 protein and C-erb B2、Bc1-2 and PCNA.In Duck, sC、D groups, all of tissues have positive expression of PCNA、C-erbB2、bc1-2、p53.Conclusions The expression of p53 protein and PCNA、c-erbB2、bc1-2 have a marked correlation with clinical pathological features. To combined detect all index is very important for clinical earlier diagnosis and progonosis.