幽门螺杆菌细胞毒素相关蛋白与胃癌的相关性

Study on relation between gastric cancer and helicobacter pylori with CagA protein

目的探讨幽门螺杆菌细胞毒素相关蛋白与胃癌的相关性。方法采用免疫印迹法检测218例慢性浅表性胃炎(CSG) 、慢性萎缩性胃炎(CAG) 和胃癌(GC)患者血清细胞毒素相关蛋白抗体(CagA)。结果CagA抗体在218例患者中总检出率为69.27%。在慢性浅表性胃炎、慢性萎缩性胃炎、胃癌患者中CagA抗体阳性率分别为55.43,74.11和90.24%,经χ2检验χ2分割法显示:三组胃疾病阳性率总体间差异有显著性;慢性浅表性胃炎与慢性萎缩性胃炎阳性率比较,差异有显著性;慢性浅表性胃炎与胃癌阳性率比较,差异有非常显著性;慢性萎缩性胃炎与胃癌阳性率比较,差异无显著性。结论慢性萎缩性胃炎和胃癌的发生与CagA阳性Hp感染有关,定期随访CagA抗体阳性Hp感染特别是已进入慢性萎缩性胃炎阶段的患者,可能有利于胃癌的早期诊断。

Objective: To investigate the relationship between the cytotoxin associated gene A (CagA) of the helicobacter pylori (Hp) and the occurrence of gastric cancer. Methods: The studied population comprised 218 patients with chronic superficial gastritis (CSG), chronic atrophic gastritis (CAG) and gastric cancer (GC). CagA in serum were measured by immunoblotting. Results: The total positive rates of CagA in serum were 69.27%. In the patients with chronic superficial gastritis (CSG), chronic atrophic gastritis (CAG) and gastric cancer (GC) were 55.43%, 74.11% and 90.24%. The total positive rates in three groups with gastric diseases were statistically different. There were significant differences among CSG and CAG, CSG and GC. There were no significant differences between CAG and GC. Conclusions: There are relationships between the CagA positive rate of helicobacter pylori (Hp) and the occurrence rate of chronic atrophic gastritis and gastric cancer. It is of benefit to diagnosis of early gastric cancer in the patients with CagA positive helicobacter pylori, especially with the chronic atrophic gastritis.