疏肝和胃汤对功能性消化不良大鼠血胃动素和胃泌素的影响

Effect of Shugan Hewei Decoction on Motilin and Gastrin in Blood of Functional Dyspepsia Rats

目的 :观察疏肝和胃汤对功能性消化不良 (FD)大鼠血中胃动素 (MOT)和胃泌素 (GAS)的影响 ,从该方对胃肠激素的调节作用方面揭示其促胃动力作用机制。方法 :采用夹尾激怒法制作FD大鼠模型。实验设立了空白对照组 ,模型组 ,疏肝和胃汤大、中、小剂量组及对照组 ,各组治疗后取血 ,应用放射免疫法检测血中MOT及GAS的含量。结果 :模型组血中MOT、GAS含量显著降低 ,经治疗后 ,疏肝和胃汤组及对照组均明显升高 ,与模型组比较差异有统计学意义 (P <0 .0 5～ 0 .0 1) ,而疏肝和胃汤组及对照组之间差异无统计学意义。结论 :疏肝和胃汤升高血中MOT和GAS的含量 ,并通过其效应而发挥促胃动力作用 ,可能是该方促进胃排空的作用机制之一 ,其机制可能与莫沙比利有相似之处。

Objective: To observe the effect of Shuga n Hewei decoction (SHD) by detecting the content of motilin(MOT) and gastrin(GAS) in the blood of functional dyspepsia(FD) rats, and investigate its mechanism. Methods: FD rat model was made through irritating the rats by clamping their tails. The rats were divided into six groups randoml y: saline control group, model group, large, middle and small dosage of SHD grou p and mosapride group. After the treatment, MOT and GAS in the blood were detect ed by the method of radioimmunoassay. Results: The contents of MOT and GAS in the blood of model group decreased significantly com pared with the saline group. SHD increased the contents of MOT and GAS significa ntly compared with the model group, and there was no significant difference betw een SHD group and mosapride group. Conclusion:SHD could increase the contents of MOT and GAS in the blood to promote gastric motivity, w hich may be its main mechanism of accelerating gastric discharge and similar to that of mosapride.