柴胡疏肝散对慢性束缚应激性肝郁证大鼠的影响

Effect of Chaihu Shugan Powder on Rats with Liver-depression Syndrome Induced by Chronic Restrained Stress

目的 :研究柴胡疏肝散对慢性束缚应激性肝郁证大鼠的影响。方法 :应用慢性束缚应激方法建立肝郁证动物模型 ,观察大鼠体重、1%蔗糖水摄取量 ,放射免疫法测定血浆促肾上腺皮质激素 (ACTH)水平。结果 :柴胡疏肝散能部分对抗应激导致的大鼠体重增长缓慢和高促ACTH ,能增加应激大鼠的蔗糖水摄取量。结论 :柴胡疏肝散可调节慢性束缚应激模型大鼠的功能紊乱。

Objective: To study the effect of Chaihu Sh ugan Powder(CSP) on rats with liver-depression syndrome induced by chronic stre ss.Methods: Chronic restrained stress(CRS) was a dopted to establish the rat model of liver-depression syndrome. In the experime nt, the body weight of the rats and the consumption of 1% sugar water by the rat s were observed, and the level of ACTH in the plasma of the rats was detected by radioimmunoassay. Results: CSP could antagonize t he loss of weight and the increase of ACTH,and could increase the consumption o f 1% sugar water in rats induced by chronic stress. Conclusion : CSP can regulate the function disorder of rats with liver- depression syndrome induced by chronic restrained stress.