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视网膜中神经生长因子及其受体作用研究新进展 被引量：5

New research development of nerve growth factor and its receptor action in retina
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摘要 神经生长因子对神经系统发育过程中的生长、生存及成熟神经系统的维持都是必不可少的。但也有相反的报道 ,NGF可通过神经营养素低亲和型受体 p75 NTR诱导细胞凋亡的发生。我们综述了NGF这两方面的内容 ,着重介绍神经生长因子及其受体在视网膜的分布和作用以及p75 NTR介导细胞凋亡的机制。 Nerve growth factor(NGF) is essential for growth and survival in the developing nervous system ,and it is also vital for the maintenance of the mature nervous system. However,recent data point to a paradoxical role for nerve growth factor .Under specific conditions,NGF can mediate apoptosis by the lower affinity neurotrophin receptor p75(p75 NTR ).In the paper,distribution and function of nerve growth factor with its receptor in the retina and the apoptosis induction through the lower affinity neurotrophin receptor p75 NTR are reviewed,and retinal neurodegeneration in nerve growth factor are also introduced.
作者 王晓英 钱焕文
机构地区 军事医学科学院放射医学研究所激光医学研究室
出处 《眼科新进展》 CAS 2004年第4期320-322,共3页 Recent Advances in Ophthalmology
关键词 视网膜 神经生长因子 TRKA P75^NTR retina nerve growth factor TrkA p75 NTR
分类号 R774.1 [医药卫生—眼科]
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参考文献26

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  • 2Amendola T, Aloe L. Developmental expression of nerve growth factor in the eye of rats affected by inherited retinopathy: correlative aspects with retinal structural degeneration[J]. Arch Ital Bio1 2002; 140(2) :81-90.
  • 3Casademunt E, Carter BD, Benzel I, Frade JM, Dechant G, Barde YA. The zinc finger protein NRIF interacts with the neurotrophin receptor p75 (NTR) and participates in programmod cell death[ J].EMBO J 1999; 18(21 ):6050-6061.
  • 4Mukai J, Hachiya T, Shoji-Hoshino S, Kimura MT,Nadano D, Suvanto P, et al. NADE, a p75NTR-associated cell death executor, is involved in signal transduction mediated by the common neurotrophin receptor p75NTR [J]. J Biol Chem 2000;275(23):17566-17570.
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眼科新进展
2004年 第4期

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