CD62p、CD63、C-RP在急性冠状动脉综合征中的作用

Role of CD62p,CD63 and C-RP in acute coronary syndrome

目的 研究血小板活化和炎症反应在急性冠状动脉综合征 (ACS)中的作用。方法 采用全血流式细胞术测定 ACS患者 5 0例和正常对照组 30例血小板胞浆内α-颗粒上的膜糖蛋白 (CD6 2 p)、溶酶体膜糖蛋白 (CD6 3) ,用速率散射比浊法测定血浆 C-反应蛋白 (C- Rective Protein,C- RP)。结果 ACS组血小板表面活性标志蛋白 CD6 2 p(11.2 1± 0 .84 ) %、CD6 3(4 .17± 0 .4 5 ) %和 C- RP(19.16± 2 .5 8) m g/ L均明显高于对照组 (3.31± 0 .6 2 ) %、(1.5 2±0 .4 1) %和 (5 .12± 1.4 3) m g/ L(P<0 .0 1) ;CD6 2 p、CD6 3与 C- RP呈显著正相关 (相关系数分别为 0 .4 2 8和 0 .4 6 9,均 P<0 .0 1)。结论 ACS患者存在血小板活性增强和炎症反应 ,这些变化与 ACS的病理过程有关。

Objective To investigate the role of platelet activation and acute inflammation in the pathogenesis of Acute coronary syndrome (ACS). MethodsPlatelet activation factor CD62p,CD63 were detected by flow cytometry and the plasma C-Rective Protein (C-RP ) was measured by rate nephelometry in 50 patients with Acute coronary syndrome and 30 normal subjects. Results Platelet activation factor CD62p,CD63 and C-RP in patients with Acute coronary syndrome were significantly higher than those of the normal subjects(P< 0.01); There were highly positive correlation between platelet CD62p,CD63 and plasma C-RP (r=0.428,r= 0.469).ConclusionPatients with Acute coronary syndrome show evidence of platelet activation and inflammation, which relate to pathophysiological process of ACS