异丙酚在胃镜检查中的应用研究

Study on gastroscopy with propofol

目的 探讨异丙酚静脉麻醉在胃镜检查中的最低有效剂量。方法 选择 6 0例胃镜检查的患者随机分为三组 ,分别静脉注射异丙酚 1mg/kg(A组 )、1 5mg/kg(B组 )、2mg/kg(C组 ) ,注射速度均为 2 0mg/10s,观察记录术中镇静效果 ,不良反应 ,用药前、中、后心率、血压、血氧饱和度变化。结果 B组及C组镇静效果明显优于A组 ,不良反应少于A组 (P <0 0 5 ) ;三组用药中与用药前比较血压、心率有一过性下降 ,C组下降最明显 (P <0 0 1) ,C组下降幅度明显大于A组、B组 (P <0 0 1和P <0 0 5 ) ;A组、B组血氧饱和度变化不大 (P >0 0 5 ) ,而C组术中血氧饱和度下降明显 ,与术前比较差异有显著意义 (P <0 0 1)。结论 异丙酚静脉麻醉用于胃镜检查是有效的 ,剂量控制在 1

Objective To discuss the lowest effective anesthesia dose of propofol in gastroscopy.Methods Sixty patients were divided into three groups:A,B,C group and were given intravenous propofol 1mg/kg,1.5mg/kg,2mg/kg.The changes of blood pressure,heart rate and blood oxygen saturation,sedative effect,adverse reaction were recorded and analyzed.Results Sedative effect of B,C group was better than that of A group,adverse reaction of B,C group was lower than that of A group(P<0.05).The blood pressure,heart rate were decreased temporary during examination in three groups.It was most significant in C group(P<0.01) and the decreased degree of C group was significant higher than A,B group(P<0.01 and P<0.05).There was no significant difference in blood oxygen saturation of A,B group(P>0.05) while blood oxygen saturation of C group was significant decreased during examination(P<0.01).Conclusion The lowest effective anesthesia dose of propofol in gastroscopy is 1.5mg/kg.