急性等容血液稀释用于脑膜瘤切除术的临床研究

Clinical studied of acute normovolemic hemodilution in meningioma operation

目的 观察脑膜瘤切除手术患者应用急性等容血液稀释 (ANH)自体输血的临床效果。方法 择期脑膜瘤切除术患者 4 0例 ,随机分为Ⅰ组 (血液稀释组 ,n =2 0 )和Ⅱ组 (对照组 ,n =2 0 ) ,两组患者均采用相同的麻醉方法全麻气管插管 ,Ⅰ组术前进行等容血液稀释。比较两组患者输异体血量和术后血红蛋白变化。结果 Ⅰ组 12例患者未输异体血 ,8例输异体血 2 0 0～ 4 0 0ml,Ⅱ组每例患者均需异体血输入 ,输血量4 0 0～ 80 0ml。

Objective To observe the clinical application of acute normovolemic hemodilutiion(ANH) on patients undergoing surgical resection meningioma and the effects on the reduction of heterologous blood transfusion.Methods 40 scheduled mengingioma surgical patients were randomly divided into group Ⅰ(ANN,n=20) and group Ⅱ(control,n=20).All patients had same general anesthetic techniques.Amounts of heterologous blood transfusion and changes of postoperative hemoglobin in two group's patients were recorded and compared.Results In ANN group 12 patients had no heterologous blood transfusion,8 patients had 200～400ml of heterologous blood transfusion.In control group all patients had heterologous blood transfusion from 400～800ml.Conclusion Acute normovolemic hemodilution can significantly reduce the volumes of heterologous blood transfusion in mengingioma surgical patients.