摘要
目的探讨E钙粘素和β连环素表达与妊娠滋养细胞疾病(GTD)恶性转化的相关性。方法应用逆转录聚合酶链反应技术检测12例正常早孕绒毛和35例妊娠滋养细胞疾病组织中E钙粘素mRNA和β连环素mRNA的表达。结果E钙粘素和β连环素mRNA在正常早孕绒毛与葡萄胎组织的表达差异无显著性(P>0.05);而在正常早孕绒毛、葡萄胎组织的表达量明显高于侵蚀性葡萄胎、绒癌组织(P<0.05);在侵蚀性葡萄胎组织的表达高于绒癌组织(P<0.05)。结论E钙粘素和β连环素的表达下调与妊娠滋养细胞疾病的恶性转化有关,对预测妊娠滋养细胞疾病的恶变以及评价预后有一定的参考价值。
Objective:To investigate the expressions of E cadherin and beta catenin mRNA and their correlation with the malignant progression in gestational trophoblastic diseases(GTD).Method:E cadherin and beta catenin mRNA in samples from 12 normal chorionic villus and 35 cases of GTD were detected by reverse transcription polymerase chain reaction.Results:No significant difference was found in the levels of E cadherin and beta catenin mRNA between hydatidiform mole and normal chorionic villus(P>0.05).While the levels of them in normal chorionic villus and hydatidiform mole were significantly higher than those in invasive hydatidiform mole and choriocarcinoma (P<0.05).The levels of them in the tissues of invasive hydatidiform mole were higher than those in choriocarcinoma (P<0.05).Conclusion:The down regulation of the E cadherin and β catenin expression is involved in the malignant progresstion of GTD.It may be valuable to detect them for the prediction of malignant transformation and evaluation of prognosis in GTD.
出处
《现代妇产科进展》
CSCD
2004年第4期270-272,共3页
Progress in Obstetrics and Gynecology