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血管内皮生长因子在异位和在位子宫内膜中的表达 被引量：2

Expression of vascular endothelial growth factor in ectopic and eutopic endometrium in patients with endometriosis.
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摘要 目的研究血管内皮生长因子(vascularendothelialgrowthfactor,VEGF)在子宫内膜异位症(endometriosis,EM)患者的异位和在位内膜中的表达。方法用免疫组化SP法分别检测45例EM患者(研究组)的异位和在位内膜及32例子宫肌瘤(对照组)的增殖期和分泌期内膜中VEGF的表达强度。结果在整个月经周期中,研究组异位和在位内膜中VEGF表达均持续高于对照组(P<0.01)。结论VEGF在EM患者异位和在位内膜中的持续过度表达可能与EM的发生发展有关。在位内膜VEGF高表达可望成为诊断EM的新方法。 Objective:To study the expression of vascular endothelial growth factor(VEGF) in ectopic and eutopic endometrium in patients with endometriosis.Method:Using immunohistochemistry SP method,the expression intensity of VEGF was examined in proliferative phase and secretive phase of ectopic endometrium and eutopic endometrium (45 cases),compared with endometrium from hysteromyoma patients(32 cases).Result:The expression rate of VEGF was persistently higher in ectopic endometrium and eutopic endometrium than that of control group (P<0.01).Conclusion:The persistently exaggerated expression of VEGF in ectopic endometrium and eutopic endometrium in patients with EM may be related to the pathogenesis of EM.The expression of high VEGF in eutopic endometrium is expected to become one of the new diagnosis methods of EM.
作者 陈琼华 曲军英 钟山 方庆全 马炎辉
机构地区 福建医科大学附属厦门第一医院妇产科 福建医科大学附属第一医院妇产科
出处 《现代妇产科进展》 CSCD 2004年第4期279-280,283,共3页 Progress in Obstetrics and Gynecology
基金 厦门市科研基金资助(2001V4)
关键词 子宫内膜异位症 内皮生长因子 子宫内膜 诊断 Endometriosis Endothelial growth factors Endometrium Diagnosis
分类号 R711.71 [医药卫生—妇产科学]
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共引文献530

同被引文献15

  • 1陈琼华,曲军英,许雅云,邱娜璇,庄严阵,钟山,方庆全.基质金属蛋白酶-9及其抑制剂在异位和在位子宫内膜组织中的表达[J].中华妇产科杂志,2004,39(12):809-812. 被引量：17
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现代妇产科进展
2004年 第4期

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