期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

血管内皮生长因子在异位和在位子宫内膜中的表达 被引量：2

Expression of vascular endothelial growth factor in ectopic and eutopic endometrium in patients with endometriosis.
下载PDF
导出
摘要 目的研究血管内皮生长因子(vascularendothelialgrowthfactor,VEGF)在子宫内膜异位症(endometriosis,EM)患者的异位和在位内膜中的表达。方法用免疫组化SP法分别检测45例EM患者(研究组)的异位和在位内膜及32例子宫肌瘤(对照组)的增殖期和分泌期内膜中VEGF的表达强度。结果在整个月经周期中,研究组异位和在位内膜中VEGF表达均持续高于对照组(P<0.01)。结论VEGF在EM患者异位和在位内膜中的持续过度表达可能与EM的发生发展有关。在位内膜VEGF高表达可望成为诊断EM的新方法。 Objective:To study the expression of vascular endothelial growth factor(VEGF) in ectopic and eutopic endometrium in patients with endometriosis.Method:Using immunohistochemistry SP method,the expression intensity of VEGF was examined in proliferative phase and secretive phase of ectopic endometrium and eutopic endometrium (45 cases),compared with endometrium from hysteromyoma patients(32 cases).Result:The expression rate of VEGF was persistently higher in ectopic endometrium and eutopic endometrium than that of control group (P<0.01).Conclusion:The persistently exaggerated expression of VEGF in ectopic endometrium and eutopic endometrium in patients with EM may be related to the pathogenesis of EM.The expression of high VEGF in eutopic endometrium is expected to become one of the new diagnosis methods of EM.
作者 陈琼华 曲军英 钟山 方庆全 马炎辉
机构地区 福建医科大学附属厦门第一医院妇产科 福建医科大学附属第一医院妇产科
出处 《现代妇产科进展》 CSCD 2004年第4期279-280,283,共3页 Progress in Obstetrics and Gynecology
基金 厦门市科研基金资助(2001V4)
关键词 子宫内膜异位症 内皮生长因子 子宫内膜 诊断 Endometriosis Endothelial growth factors Endometrium Diagnosis
分类号 R711.71 [医药卫生—妇产科学]
  • 相关文献

参考文献5

二级参考文献10

  • 1Ishimura T, Masuzaki H. Peritoneal endometriosis: endometrial tissue implantation as its primary etiologic mechanism[ J ]. Am J Obstet Gyneeol, 1991, 165( 1 ) :210-214.
  • 2Folkman J, Shing Y. Angiogenesis[ J]. J Biol Chem, 1992, 267(16) : 10931-10934.
  • 3Donnez J, Smoes P, Gillerot S, et al. Vascular endothelial growth factor (VEGF) in endometriosis [ J ]. Hum Reprod,1998, 13(6) : 1686-1690.
  • 4Dvorak HF, Brown LF, Detmar M, et al. Vasclular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis[ J]. Am J Pathol, 1995, 146 : 1029-1039.
  • 5Bussolino F, Mantovani A, Persico G. Molecular mechanisms of blood vessel formation[J]. TIBS, 1997, 22(7) :251-256.
  • 6McLaren J, Prentice A, Charnock-Jones DS, et al. Vascular endothelail growth factor is produced by peritoneal fluid macrophages in endometriosis and is regulated by ovarian steroids [ J ]. J Clin Invest, 1996, 98:482-489.
  • 7Fujishita A, Hasuo A, Khan KN, et al. Immunohistochemical study of angiogenic factor in endometrium and endometriosis[ J ].Gynecol Obstet Invest, 1999, 48( suppl 1 ) : 36--44.
  • 8Smith SK. Vascular endothelial growth factor and the endometrium[J]. Hum Reprod, 1996, 11: 56-61.
  • 9McLaren J, Prentice A, Charnock-Jones DS, et al. Vascular endothelial growth factor(VEGF) concentrations are elevated in peritoneal fluid of women with endometriosis[ J]. Hum Reprod,1996, 11 : 220-223.
  • 10刘启功,颜进,张卫东,陆再英.hVEGF_(165)基因转移对血管内皮细胞增殖及分泌功能的实验研究[J].中华血液学杂志,2000,21(9):489-490. 被引量：7

共引文献530

同被引文献15

  • 1陈琼华,曲军英,许雅云,邱娜璇,庄严阵,钟山,方庆全.基质金属蛋白酶-9及其抑制剂在异位和在位子宫内膜组织中的表达[J].中华妇产科杂志,2004,39(12):809-812. 被引量：16
  • 2Giudice L C, Kao L C. Endometriosis [J].Lancet, 2004,364 (9447) :1789 - 1799.
  • 3Machado D E, Abrao M S, Berardo P T, et al. Vascular density and distribution of vascular endothelial growth factor (VEGF) and its receptor VEGFR-2(Flk-1 ) are significantly higher in patients with deeply infiltrating endometriosis affecting the rectum[J ]. Fertil Steril,2008 ,90 :148 - 155.
  • 4Huang H F,Hong L H,Tan Y, et al. Matrix mctalloproteinase-2 is associated with changes in steroid hormones in the sera and peritoneal fluid of patients with endometriosis[J]. Fertil Steril,2004,81:1235 - 1239.
  • 5Li T, Li YG, Pu DM. Matrix metalloproteinase-2 and-9 expression correlated with angiogenesis in human adenomyosis. Gynecol Obstet Invest,2006,62:229 - 235.
  • 6McLaren J. Vascular endothelial growth factor and endometriotic angiogenesis [J ]. Hum Reprod Update,2000,6:45 - 55.
  • 7Bourlev V,Volkov N,Pavlovitch S,et al. The relationship between microvessel density, proliferative activity and expression of vascular endothelial growth factor-A and its receptors in eutopic endometrium and endometriotic lesions [J ]. Reproduction,2006,132:501 - 509.
  • 8周剑萍.生殖激素受体测定[M]//李诵炫,于传鑫,主编.实用妇产科内分泌学.上海:上海医科大学出版社,2000:295-300.
  • 9Kitawaki J, Kado N. Endometriosis: the pathophysiology as an estrogen-dependent disease [J ]. J Steroid Biochem Mol Biol,2002,83 (1/5) : 149 - 155.
  • 10Mathias SD,Kuppermand M,Liberman RF,et al.Chronic pelvic pain: prevalence, health-related quality of life, and economic correlatesObstetrics and Gynecology Annual,1996.

引证文献2

二级引证文献10

现代妇产科进展
2004年 第4期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部