精神分裂症患者血清唾液酸含量研究

A correlative study of blood saliva acid levels and clinical effects in patients with schizophrenia.

目的 :探讨精神分裂症患者血清唾液酸 (SA)含量的变化及其临床意义。 方法 :86例首发精神分裂症患者用利培酮治疗 6个月 ,于治疗前及治疗第 1、3、6个月末采取血液标本进行血清SA含量测定 ,同时用阳性与阴性症状量表 (PANSS)评定疗效 ,并与 32名健康者 (正常对照组 )进行比较。 结果 :精神分裂症患者血清SA含量明显高于对照组。治疗后逐渐下降 ,到第 6个月末最明显 ,且与PANSS总分的降低值呈显著正相关。 结论 :精神分裂症患者发病期间血清SA含量增高 ,可能与精神病理学改变有关。

Objective:To explore the relationship between the blood saliva acid (SA) levels and clinical effects in patients with schizophrenia. Method:86 patients who met the CCMD-3 for schizophrenia were treated with risperidone for 6 months.The blood SA levels were tested and the clinical effects were rated with PANSS before and after treatment 1,3 and 6 months.32 normal controls were included in the study. Results:The blood SA levels were significantly higher in the study group than in the normal controls,and reduced gradually after treatment. There was significant positive correlation between the blood SA levels and the PANSS rating scores. Conclusion:The blood SA levels may be higher in patients with schizophrenia.