硫酸亚铁预防氯丙嗪致锥体外系反应的效果

A comparative trial on the efficacy of ferrous sulfate and benzhexol in the prevention of EPS

目的 :探讨硫酸亚铁预防氯丙嗪所致锥体外系 (EPS)不良反应的疗效和安全性。 方法 :将 80例精神分裂症患者随机分为两组。硫酸亚铁组为氯丙嗪合并硫酸亚铁治疗 ,苯海索组为氯丙嗪合并苯海索治疗 ,时间 6周。采用锥体外系不良反应量表 (ESRS)、副反应量表 (TESS)和简明精神病评定量表 (BPRS)评定疗效及不良反应。 结果 :硫酸亚铁组EPS发生率与苯海索组差异无显著性 ,硫酸亚铁组ESRS震颤、静坐不能出现的频率显著低于苯海索组。 结论 :硫酸亚铁对EPS具有良好的防治作用 ,不良反应小。

Objective:To explore the efficacy and security of ferrous sulfate in the prevention of EPS induced by chlorpromazine. Method:By randomized double blind method, 80 cases of schizophrenia were divided into the study group with chlorpromazine and ferrous sulfate,and the control group with chlorpromazine and benzhexol for 6 weeks. The therapeutic response and side effects were evaluated with BPRS,ESRS and TESS. Results:The prevalence of EPS in two groups had no significant difference.The frequency of tremor and akathisia in research group were lower than that in control group. Conclusion:Ferrous sulfate has good effect on prevention and cure of EPS ,with mild side effects.