降糖中药1号药效学的研究

Pharmacodynamical Research on Blood-Sugar Lowering TCM Drug No.1

目的 研究降糖中药 1号的作用机理 ,为临床提供科学的用药依据。方法 取健康小鼠 ,随机分组 ,每组 11～ 12只。设阴性对照组、阳性对照组、模型组、中药大剂量组、中药小剂量组 ,连续灌胃给药 ,每天 1次 ,每次 0 6 5mL。取血 ,离心 ,检测血糖、SOD含量和用显微视像循环仪测定小鼠耳廓微循环的变化。结果 降糖中药 1号能明显降低高血糖小鼠的血糖 ,同时 ,加快小鼠耳廓小动脉的血流速度 ,提高血中超氧化物歧化酶 (SOD)的活性。结论 降糖中药 1号对小鼠的血糖、微循环和超氧化物歧化酶 (SOD)具有显著的影响。

Objective To investigate the mechanism of the effect of Blood-Sugar Lowering TCM Drug No.1 (BSLD No.1) in order to provide experimental data for its clinical administration. Method Healthy mice were randomly divided into groups,and each group had 11-12 of them. The negative control group,positive control group,model group,BSLD No.1 large dose group,and BSLD No.1 small dose group were set up in the experiment. BSLD No.1 was successively given to the mice intragastrically,once a day,0.65 mL each time. The levels of blood sugar and SOD were detected and the changes in the auricle microcirculation were detected with a microvisual circulation apparatus. Results BSLD No.1 could markedly decrease the level of blood-sugar in the hyperglycemic mouse,promote the velocity of blood flow of mouse auricle arterioles,and enhance the activity of SOD in the blood of the mouse. Conclusion BSLD No.1 has remarkable effects on blood-sugar,microcirculation and SOD in the mouse.