稀土作业工人尿中N-乙酰-β-D氨基葡萄糖苷酶活性的初步研究

STUDY ON N-ACETYL-β-D-GLUCOSAMINIDASE ACTIVITY IN URINE OF WORKERS IN RARE-EARTH METAL INDUSTRY

尿中N-乙酰-β-D氨基葡萄糖苷酶(NAG)活性能反映肾实质进行性和破坏性损害,是一项检测肾实质受损的敏感指标。为了解稀土粉尘对作业工人肾脏是否有不良影响,对接触稀土粉尘的部分男性工人尿中NAG活性进行了测定。结果表明,不接触稀土粉尘者尿中NAG活性为19.9±2.5U/gCr,接触者为17.5±3.1～87.1±2.1U/gCr,以原料工和纯稀土冶炼工为高,与非接触组之间有显著性差异。但对接触稀土粉尘者尿中NAG活性升高是否由稀土所致,还需要对接触者肾功能进行全面检测研究。

The activity of N-acetyl-β-D-glucosaminidase (NAG) in urine is one of the sensitive induces for monitoring the damage of renal parenchyma because it can reflect the progressive and destructive damage of kidney. In order to s.tudy whether the rare-earth dust might have some harmful effects on worker's kidney, the activity of NAG in the male worker's urine had been examined.The results show that the NAG activity in urine of control workers was l9.9±2.5U/gCr while the activity of NAG in urine of the dust-exposed workers was l7.5±3.1 U/gCr-87.1 ±2.lU/gCr.Workers exposed to raw material and smelters were especially high and gave significant difference with the control group.Further studies are needed in order to make clear that the rare-earth dust can increase the activity of NAG in urine of the dust-exposed group.