耐多药相关蛋白、P-糖蛋白在非小细胞肺癌中的表达及临床意义

Expression and clinical significance of multi-drug resistance associated protein and P-glycoprotein in non-small-cell lung cancer

目的 观察耐多药相关蛋白 (MRP)、P 糖蛋白 (P gp)在肺癌组织中的表达情况 ,以及MRP与P gp之间的相关性 ,探讨MRP、P gp与患者预后的关系。 方法 应用链霉亲和素 生物素过氧化物酶复合物 (S P)免疫组化法检测MRP、P gp的表达情况。结果 4 2例非小细胞肺癌中MRP阳性率为 4 5 .2 % ,腺癌中的MRP的表达明显高于鳞癌 (P <0 .0 5 ) ;P gp阳性表达率为4 0 .4 % ,P gp的表达与组织类型、细胞分化水平、TNM临床分期无关 (P >0 .0 5 ) ;肺癌组织中P gp与MRP的表达具有明显相关性 (P <0 .0 1) ;MRP、P gp阴性患者术后 3年无病生存期明显高于MRP、P gp阳性患者 (P <0 .0 5 )。结论 MRP、P

Objective To observe the expression of the multi-drug resistance associated protein(MRP) and P-glycoprotein(P-gp) in non-small cell lung cancer(NSCLC) tissues, and the relationship between MRP,P-gp and the prognosis of patients' conditions. Methods The expressions of MRP and P-gp in NSCLC were measured by using the S-P immunohistochemistry. Results Among the 42 cases, the positive rate of MRP in NSCLC was 45.2%,the expression of MRP in adeno-carcinoma was higher than that in squamous carcinoma(P< 0.05); the positive rate of P-gp in lung cancer tissue was 40.4%,the expression of P-gp was not related to patients' sex,age,clinical stage, differentiation degree of tumor cells(P> 0.05),the expressions of P-gp and MRP had positive correlation in lung cancer (P< 0.01). The non-tumor survival rate of three year postoperative of negative patients with MRP and P-gp in lung cancer was longer than that in the positive patients with MRP and P-gp (P< 0.05). Conclusion P-gp and MRP can be taken for a referential index to judge the clinical effect of the chemotherapy and evaluate prognosis of patients with lung cancer.