参桂胶囊对大鼠心肌梗死后心功能影响的研究

Effect of Shengui Capsule on Cardiac Function of Rats with Experimental Myocardial Infarction

目的 观察参桂胶囊对大鼠急性心肌梗死 (AMI)后心功能不全心室重构 (VR)的干预作用。方法 结扎Wistar大鼠冠状动脉左前降支 ,标准肢导联Ⅱ导心电图示ST段弓背抬高 ,证实AMI形成后 ,将大鼠随机分为 7组 ,于手术后第 2天开始灌胃给药 ,连续 8周。然后经左颈总动脉插管观察大鼠的心脏功能。结果 与模型组比较 ,参桂胶囊大、中剂量组和卡托普利 (开博通 )组皆可明显降低AMI大鼠心脏指数和左室舒张末压 (P <0 .0 5～P <0 .0 1) ,增加左室收缩末压(P <0 .0 1)和 +dp/dtMax(P均 <0 .0 5或P <0 .0 1)。结论 参桂胶囊可显著降低AMI大鼠左室重量和心脏指数 ,改善心脏收缩及舒张功能 ,对AMI后心功能不全大鼠心室重构具有一定的干预作用。

Objective To observe the effects of Shengui capsule on ventricular remodeling(VR) in cardiac dysfunction rats after acute myocardial infarction(AMI).Methods Left anterior descending branch of coronary artery of wistar rats were ligated. Rats showed ST-T segment elevation in lead Ⅱof electrocardiogram were proved to be AMI rats. AMI rats were then divided randomly to seven groups and test drugs were given in succession for 8 weeks. Cardiac function was observed by left common carotid artery intubation.Results Compared with the model group, both high and medium dosage of Shengui capsule groups and captopril group significantly lowered cardiac index and left ventricular end-diastolic pressure(P<0.01) and increased left ventricular end-systolic pressure(P<0.01)and +dp/dtMax(P<0.05～P<0.01).Conclusion Shengui capsule could significantly lower left ventricular weight and cardiac index ,and could improve cardiac systolic and diastolic function.Shengui capsule had the effect of preventing VR after AMI.