灯盏乙素抗炎作用的实验研究

Experimental Study on Anti-inflammation Influence of Scutellarin

目的 :研究灯盏乙素的抗炎作用。方法 :采用对小鼠或大鼠灌胃及给药的途径。设人体剂量的 5倍、1 0倍、1 5倍 3个剂量组 ,以地塞米松作为阳性对照组 ,用小鼠耳廓肿胀法 (急性炎症 )、大鼠塑料环肉芽肿法 (慢性炎症 )实验方法 ,作药效比较。结果 :灌胃给予灯盏乙素 1 0 0mg/kg·d、2 0 0mg/kg·d、30 0mg/kg·d均能抑制小鼠耳廓肿胀 (P <0 .0 1 ) ;并能抑制大鼠肉芽增生 (P <0 .0 1 )。结论 :灯盏乙素有抗急、慢性炎症作用 。

Objective:To study the anti-inflammation effects Of scutellarin.Methods:Thefunctions of scutellarin were observed by intragastrlc administration to mice or rats.The testmethods were auricular tume faction in mice,plastic ring granuloma in rats.Results:Intragastrlcadministration of l00mg/kg/d could inhibit auricular tumefacfion in mice and granulomahyperplasia(100mg/kg/d).Conclusion:Scutellarin lntragastrac administration can inhibitacute orchronic inflammation in mice or rats.